Resenha
Haloperidol (but not ziprasidone) withdrawal enhances cocaine-induced locomotor activation and conditioned place preference in mice
Fecha
2007-05-09Registro en:
Progress in Neuro-psychopharmacology & Biological Psychiatry. Oxford: Pergamon-Elsevier B.V., v. 31, n. 4, p. 867-872, 2007.
0278-5846
10.1016/j.pnpbp.2007.01.025
WOS:000246931200010
Autor
Fukushiro, Daniela Fukue
Alvarez, Juliana do Nascimento
Obara Tatsu, Julie Anne
Vilela de Castro, Juliana Pedroso Moraes
Chinen, Cibele Cristina
Frussa-Filho, Roberto
Institución
Resumen
It has been empirically suggested that the high incidence of drug abuse in schizophrenic patients is related to chronic neuroleptic treatment. We investigated the effects of withdrawal from long-term administration of the typical neuroleptic haloperidol and/or the atypical agent ziprasidone on the acute locomotor stimulant effect of cocaine as well as on cocaine-induced conditioned place preference (UP). in the first experiment, mice were i.p. treated with haloperidol (1.0 mg/kg) and/or ziprasidone (4.0 mg/kg) for 15 days. At 72 h after the last injection, animals received an i.p. injection of cocaine (10 mg/kg) and their locomotor activity was quantified. in the second experiment, mice were withdrawn from the same haloperidol or ziprasidone treatment schedule and submitted to CPP. Withdrawal from haloperidol (but not ziprasidone or ziprusidone plus haloperidol) increased both cocaine-induced hyperactivity and CPR These findings indicate that withdrawal from long-term treatment with typical neuroleptic drugs such as haloperidol (but not the atypical compound ziprasidone) may enhance some behavioral effects of cocaine in mice which have been related to drug dependence in humans. (c) 2007 Elsevier Inc. All fights reserved.