Traumatic spinal cord injury: current concepts and treatment update

dc.creatorRouanet, Carolina [UNIFESP]
dc.creatorReges, Danyelle [UNIFESP]
dc.creatorRocha, Eva [UNIFESP]
dc.creatorGagliardi, Vivian [UNIFESP]
dc.creatorSilva, Gisele Sampaio [UNIFESP]
dc.date.accessioned2020-07-13T11:52:56Z
dc.date.accessioned2022-10-07T21:04:46Z
dc.date.available2020-07-13T11:52:56Z
dc.date.available2022-10-07T21:04:46Z
dc.date.created2020-07-13T11:52:56Z
dc.date.issued2017
dc.identifierArquivos De Neuro-Psiquiatria. Sao Paulo Sp, v. 75, n. 6, p. 387-393, 2017.
dc.identifier0004-282X
dc.identifierhttps://repositorio.unifesp.br/handle/11600/54330
dc.identifierS0004-282X2017000600387.pdf
dc.identifierS0004-282X2017000600387
dc.identifier10.1590/0004-282X20170048
dc.identifierWOS:000404476400011
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/4026654
dc.description.abstractSpinal cord injury (SCI) affects 1.3 million North Americans, with more than half occurring after trauma. In Brazil, few studies have evaluated the epidemiology of SCI with an estimated incidence of 16 to 26 per million per year. The final extent of the spinal cord damage results from primary and secondary mechanisms that start at the moment of the injury and go on for days, and even weeks, after the event. There is convincing evidence that hypotension contributes to secondary injury after acute SCI. Surgical decompression aims at relieving mechanical pressure on the microvascular circulation, therefore reducing hypoxia and ischemia. The role of methylprednisolone as a therapeutic option is still a matter of debate, however most guidelines do not recommend its regular use. Neuroprotective therapies aiming to reduce further injury have been studied and many others are underway. Neuroregenerative therapies are being extensively investigated, with cell based therapy being very promising.
dc.languageeng
dc.publisherAssoc Arquivos Neuro- Psiquiatria
dc.relationArquivos De Neuro-Psiquiatria
dc.rightsAcesso aberto
dc.subjectspinal cord injuries
dc.subjectspinal cord compression
dc.subjectneurosurgery
dc.subjectspinal cord regeneration
dc.subjectcell- and tissue-based therapy
dc.titleTraumatic spinal cord injury: current concepts and treatment update
dc.typeArtigo


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