Hormonal alteration in obese adolescents with eating disorder: Effects of multidisciplinary therapy

dc.contributorUniversidade Federal de São Paulo (UNIFESP)
dc.creatorCarnier, June [UNIFESP]
dc.creatorLofrano, Mara Cristina [UNIFESP]
dc.creatorPrado, Wagner Luiz do [UNIFESP]
dc.creatorCaranti, Danielle Arisa [UNIFESP]
dc.creatorPiano, Aline de [UNIFESP]
dc.creatorTock, Lian [UNIFESP]
dc.creatorNascimento, Claudia Maria da Penha Oller do [UNIFESP]
dc.creatorOyama, Lila Missae [UNIFESP]
dc.creatorMello, Marco Tulio de [UNIFESP]
dc.creatorTufik, Sergio [UNIFESP]
dc.creatorDâmaso, Ana Raimunda [UNIFESP]
dc.date.accessioned2016-01-24T13:49:27Z
dc.date.accessioned2022-10-07T21:02:50Z
dc.date.available2016-01-24T13:49:27Z
dc.date.available2022-10-07T21:02:50Z
dc.date.created2016-01-24T13:49:27Z
dc.date.issued2008-01-01
dc.identifierHormone Research. Basel: Karger, v. 70, n. 2, p. 79-84, 2008.
dc.identifier0301-0163
dc.identifierhttps://repositorio.unifesp.br/handle/11600/30356
dc.identifier10.1159/000139148
dc.identifierWOS:000257518300003
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/4026375
dc.description.abstractBackground/Aims: Ghrelin and leptin play important roles in the physiopathology of eating disorders, starting generally in infancy and adolescence. the aim of this study was to evaluate the effects of multidisciplinary short-term therapy on ghrelin and leptin concentrations, bulimia nervosa symptoms, binge eating disorder symptoms, body composition, and visceral and subcutaneous fat in obese adolescents. Methods: Twenty obese adolescents with simple obesity (BMI > 95th percentile, 36.93 +/- 4.14, CDC) were submitted to multidisciplinary ( nutrition, psychology, exercise and clinical) therapy. Plasma ghrelin and leptin concentrations were measured by radioimmunoassay. Bulimic and binge eating behaviors were measured by the Bulimic Investigation Test Edinburgh and the Binge Eating Scale, respectively. Visceral and subcutaneous fat were measured by ultrasonography and body composition by plethysmography. Results: Significant reductions were observed in body weight (101.04 +/- 11.18 to 94.79 +/- 10.94 kg), BMI (36.93 +/- 4.14 to 34.27 +/- 4.78), fat% (41.96 +/- 6.28 to 39.14 +/- 7.62%), visceral fat (4.34 +/- 1.53 to 3.41 +/- 1.12 cm), leptin concentration (20.12 +/- 6.47 to 16.68 +/- 8.08 ng/ml), prevalence of bulimia nervosa (100 to 67%) and binge eating disorder symptoms (40 to 17%). Conclusion: Short-term multidisciplinary therapy was effective in improving body composition, visceral fat, leptinemia and eating disorders in obese adolescents. Copyright (C) 2008 S. Karger AG, Basel.
dc.languageeng
dc.publisherKarger
dc.relationHormone Research
dc.rightshttp://www.karger.com/Services/RightsPermissions
dc.rightsAcesso restrito
dc.subjectLeptin
dc.subjectGhrelin
dc.subjectBinge eating disorder
dc.subjectBulimia nervosa
dc.subjectBody composition
dc.titleHormonal alteration in obese adolescents with eating disorder: Effects of multidisciplinary therapy
dc.typeArtigo


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