Artigo
Cutaneous T-cell lymphoma with HTLV-I infection: clinical overlap with adult T-cell leukemia/lymphoma
Fecha
2006-04-01Registro en:
International Journal of Dermatology. Oxford: Blackwell Publishing, v. 45, n. 4, p. 447-449, 2006.
0011-9059
10.1111/j.1365-4632.2006.02687.x
WOS:000236585200022
Autor
Sakamoto, F. H.
Colleoni, GWB
Teixeira, S. P.
Yamamoto, M.
Michalany, N. S.
Almeida, F. A.
Chiba, A. K.
Petri, V
Fernandes, M. A.
Pombo-de-Oliveira, M. S.
Institución
Resumen
Adult T-cell leukemia/lymphoma (ATLL) is a malignant proliferation of mature helper T lymphocytes, 1 and is caused by human T-lymphotropic virus type I (HTLV-I);(2) an HTLV-I infection endemic in the Caribbean, south-western Japan, South America and Africa.(3,4) Seroepidemiological studies suggest that it is also endemic in Brazil.(5) Although carriers of HTLV-I show polyclonal integration of virus in T lymphocytes, only patients with ATLL of various subtypes show monoclonal integration of HTLV-I in tumor cells.(6,7) Cutaneous T-cell lymphomas ( CTCL) are a group of primary cutaneous lymphoproliferative diseases(8) with unknown etiology.(9) the two most common presentations of CTCL are mycosis fungoides (MF) and Sezary syndrome (SS).(10-13) However, both CTCL categories can easily resemble ATLL. Therefore, in HTLV-I endemic areas, differentiation between ATLL and CTCL must be performed, as they have different prognoses and treatment approaches.(14).