Anticonvulsant and GABA uptake inhibition properties of venom fractions from the spiders Parawixia bistriata and Scaptocosa raptoria

dc.contributorUniversidade de São Paulo (USP)
dc.contributorUniversidade Federal de São Paulo (UNIFESP)
dc.creatorRodrigues, Marcelo Cairrão Araujo
dc.creatorRibeiro, Alessandra Mussi
dc.creatorPizzo, Andrea Baldocchi
dc.creatorFontana, Andreia Cristina Karklin
dc.creatorBeleboni, Renê de Oliveira
dc.creatorCoutinho-Netto, Joaquim
dc.creatorMiranda, Antonio de [UNIFESP]
dc.creatorSantos, Wagner Ferreira dos
dc.date.accessioned2016-01-24T12:33:30Z
dc.date.accessioned2022-10-07T20:53:32Z
dc.date.available2016-01-24T12:33:30Z
dc.date.available2022-10-07T20:53:32Z
dc.date.created2016-01-24T12:33:30Z
dc.date.issued2002-09-01
dc.identifierPharmaceutical Biology. Lisse: Swets Zeitlinger Publishers, v. 40, n. 6, p. 472-477, 2002.
dc.identifier1388-0209
dc.identifierhttps://repositorio.unifesp.br/handle/11600/26969
dc.identifier10.1076/phbi.40.6.472.8436
dc.identifierWOS:000179940300014
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/4024360
dc.description.abstractIn this article we describe an in vivo anticonvulsant effect from denatured crude venom and partially isolated fractions from two spiders: Parawixia bistriata and Scaptocosa raptoria. Intracerebroventricular injections of these venoms and fractions abolished rat convulsive tonic-clonic seizures induced by picrotoxin, bicuculline and pentylenetetrazole, and also, inhibited GABA uptake in synaptosomes of rat cerebral cortex. the venoms described in this work seems to be promising tools for the study of the GABAergic system, and may be a potential source for new anticonvulsant drugs.
dc.languageeng
dc.publisherSwets Zeitlinger Publishers
dc.relationPharmaceutical Biology
dc.rightsAcesso restrito
dc.subjectAnticonvulsant
dc.subjectBicuculline
dc.subjectGABA
dc.subjectGABA uptake
dc.subjectParawixia bistriata
dc.subjectPentilenetetrazole
dc.subjectPicrotoxin
dc.subjectScaptocosa raptoria
dc.subjectSpider venom
dc.subjectRat synaptosomes
dc.titleAnticonvulsant and GABA uptake inhibition properties of venom fractions from the spiders Parawixia bistriata and Scaptocosa raptoria
dc.typeArtigo


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