Insulin resistance and not steatosis is associated with modifications in oxidative stress markers in chronic hepatitis C, non-3 genotype

dc.contributorUniversidade Federal de São Paulo (UNIFESP)
dc.creatorOliveira, Ana C. [UNIFESP]
dc.creatorParise, Edison Roberto [UNIFESP]
dc.creatorCatarino, Regina M. [UNIFESP]
dc.creatorLanzoni, Valeria Pereira [UNIFESP]
dc.creatorLeite-Mór, Marilisa Moraes Barros [UNIFESP]
dc.creatorSimon, Karin Argenti [UNIFESP]
dc.creatorJunqueira, Virginia B. C. [UNIFESP]
dc.date.accessioned2016-01-24T13:52:10Z
dc.date.accessioned2022-10-07T20:53:29Z
dc.date.available2016-01-24T13:52:10Z
dc.date.available2022-10-07T20:53:29Z
dc.date.created2016-01-24T13:52:10Z
dc.date.issued2009-01-01
dc.identifierFree Radical Research. Abingdon: Taylor & Francis Ltd, v. 43, n. 12, p. 1187-1194, 2009.
dc.identifier1071-5762
dc.identifierhttp://repositorio.unifesp.br/handle/11600/31239
dc.identifier10.3109/10715760903247249
dc.identifierWOS:000272753100005
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/4024356
dc.description.abstractBackground: Modifications of oxidative stress are reported in hepatitis C. the relationship between insulin resistance (IR), steatosis and oxidative stress is not established. Materials and methods: One hundred and eighty-seven HCV-RNA patients were assessed by determination of biochemical, metabolic and viral features, HOMA-IR and morphological alterations. in the 52-non-3 genotypes sub-group and 35 healthy individuals, thiobarbituric acid (TBARS), total glutathione (total-GSH), vitamins C and E, lycopene, beta-carotene, glutathione peroxidase (GPx), catalase and superoxide dismutase were determined. Results: in non-3 genotype patients, steatosis was associated with higher values of BMI, HOMA-IR and triglycerides. in the 52-HCV sub-group, values of TBARS, GPx and total-GSH differ from the control group. Despite these, differences could not be observed according to the presence of steatosis, patients with IR presented significant differences regarding total-GSH (p = 0.019), beta-carotene (p = 0.006), lycopene (p = 0.005) and GPx (p = 0.009). Conclusion: in non-3 genotype HCV carries, IR, and not steatosis, is associated with modifications in serum levels of oxidative stress.
dc.languageeng
dc.publisherTaylor & Francis Ltd
dc.relationFree Radical Research
dc.rightshttp://journalauthors.tandf.co.uk/permissions/reusingOwnWork.asp
dc.rightsAcesso restrito
dc.subjectInsulin resistance
dc.subjectchronic hepatitis C
dc.subjecthepatic steatosis
dc.subjectoxidative stress markers
dc.subjectfibrosis
dc.titleInsulin resistance and not steatosis is associated with modifications in oxidative stress markers in chronic hepatitis C, non-3 genotype
dc.typeArtigo


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