AGE DEPENDENCY of the SUSCEPTIBILITY of RATS TO AMINOOXYACETIC ACID SEIZURES

dc.contributorUniversidade Federal de São Paulo (UNIFESP)
dc.creatorTurski, W.
dc.creatorDziki, M.
dc.creatorParada, J.
dc.creatorKleinrok, Z.
dc.creatorCavalheiro, E. A.
dc.date.accessioned2016-01-24T11:40:07Z
dc.date.accessioned2022-10-07T20:51:57Z
dc.date.available2016-01-24T11:40:07Z
dc.date.available2022-10-07T20:51:57Z
dc.date.created2016-01-24T11:40:07Z
dc.date.issued1992-06-19
dc.identifierDevelopmental Brain Research. Amsterdam: Elsevier B.V., v. 67, n. 2, p. 137-144, 1992.
dc.identifier0165-3806
dc.identifierhttp://repositorio.unifesp.br/handle/11600/25257
dc.identifier10.1016/0165-3806(92)90214-H
dc.identifierWOS:A1992JE10400003
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/4024032
dc.description.abstractImmature rats are more susceptible to clonic seizures induced by aminooxyacetic acid (AOAA) than mature and senile rats. Highest susceptibility to AOAA seizures was observed in 7-14-day-old rat pups. the lowest susceptibility was recorded in 10-20 month-old rats. AOAA seizures in 14-day-old rats were blocked by clonazepam and valproate, but not by phenobarbital, carbamazepine, diphenylhydantoin, trimethadione or ethosuximide. Morphological analysis of brains from 14-day- and 3-month-old rats which experienced AOAA seizures did not reveal epilepsy-related damage. These observations suggest that immature rat brain is highly prone to convulsions induced by AOAA and that such convulsions are difficult to control by available antiepileptic treatment.
dc.languageeng
dc.publisherElsevier B.V.
dc.relationDevelopmental Brain Research
dc.rightshttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dc.rightsAcesso restrito
dc.subjectAMINOOXYACETIC ACID
dc.subjectSEIZURE
dc.subjectANTIEPILEPTIC DRUG
dc.subjectDEVELOPMENT
dc.subjectRAT
dc.titleAGE DEPENDENCY of the SUSCEPTIBILITY of RATS TO AMINOOXYACETIC ACID SEIZURES
dc.typeArtigo


Este ítem pertenece a la siguiente institución