Granule cell dispersion is not a predictor of surgical outcome in temporal lobe epilepsy with mesial temporal sclerosis

dc.contributorUniversidade Federal de São Paulo (UNIFESP)
dc.contributorSanta Casa São Paulo
dc.contributorAFIP
dc.creatorCosta Neves, Rafael Scarpa da [UNIFESP]
dc.creatorJardim, Anaclara Prada [UNIFESP]
dc.creatorCaboclo, Luis Otavio [UNIFESP]
dc.creatorLancellotti, Carmen
dc.creatorMarinho, Taissa Ferrari [UNIFESP]
dc.creatorHamad, Ana Paula [UNIFESP]
dc.creatorMarinho, Murilo [UNIFESP]
dc.creatorCenteno, Ricardo [UNIFESP]
dc.creatorCavalheiro, Esper Abrao [UNIFESP]
dc.creatorScorza, Carla Alessandra [UNIFESP]
dc.creatorTargas Yacubian, Elza Marcia [UNIFESP]
dc.date.accessioned2016-01-24T14:31:07Z
dc.date.accessioned2022-10-07T20:50:22Z
dc.date.available2016-01-24T14:31:07Z
dc.date.available2022-10-07T20:50:22Z
dc.date.created2016-01-24T14:31:07Z
dc.date.issued2013-01-01
dc.identifierClinical Neuropathology. Deisenhofen-muenchen: Dustri-verlag Dr Karl Feistle, v. 32, n. 1, p. 24-30, 2013.
dc.identifier0722-5091
dc.identifierhttp://repositorio.unifesp.br/handle/11600/35870
dc.identifier10.5414/NP300509
dc.identifierWOS:000314623500005
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/4023672
dc.description.abstractThe aim of this retrospective study of a series of patients with mesial temporal lobe epilepsy (MTLE) and mesial temporal sclerosis (MTS) was to analyze the association of granule cell dispersion (GCD) with surgical prognosis, patterns of MTS and clinical data. Hippocampal specimens from 66 patients with MTLE and unilateral MTS and from 13 controls were studied. Quantitative neuropathological evaluation was performed on NeuN-stained hippocampal sections. Patients' clinical data, types of MTS and surgical outcome were reviewed. GCD occurred in 45.5% of cases and was not correlated with clinical variable. More severe neuronal loss was observed in patients with GCD. Except for MTS Type 2 observed only in four no-GCD patients groups did not differ with respect to the types of MTS. Surgical outcome was similar in both groups. in conclusion, GCD was associated with the degree of hippocampal cell loss, but was not a predictor of surgical outcome.
dc.languageeng
dc.publisherDustri-verlag Dr Karl Feistle
dc.relationClinical Neuropathology
dc.rightsAcesso restrito
dc.subjectmesial temporal lobe epilepsy
dc.subjectmesial temporal sclerosis
dc.subjectdentate gyrus
dc.subjectgranule cell dispersion
dc.subjectsurgical prognosis
dc.titleGranule cell dispersion is not a predictor of surgical outcome in temporal lobe epilepsy with mesial temporal sclerosis
dc.typeArtigo


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