dc.contributorUniversidade Federal de Minas Gerais (UFMG)
dc.contributorUniversidade Federal de São Paulo (UNIFESP)
dc.creatorSilveira, Katia D. da
dc.creatorBosco, Kenia S. Pompermayer
dc.creatorDiniz, Lucio R. L.
dc.creatorCarmona, Adriana Karaoglanovic [UNIFESP]
dc.creatorCassali, Giovanni D.
dc.creatorBruna-Romero, Oscar
dc.creatorSousa, Lirlandia P. de
dc.creatorTeixeira, Mauro M.
dc.creatorSantos, Robson A. S.
dc.creatorSimoes e Silva, Ana C.
dc.creatorRibeiro Vieira, Maria A.
dc.date.accessioned2016-01-24T14:05:35Z
dc.date.accessioned2022-10-07T20:50:13Z
dc.date.available2016-01-24T14:05:35Z
dc.date.available2022-10-07T20:50:13Z
dc.date.created2016-01-24T14:05:35Z
dc.date.issued2010-11-01
dc.identifierClinical Science. London: Portland Press Ltd, v. 119, n. 9-10, p. 385-394, 2010.
dc.identifier0143-5221
dc.identifierhttp://repositorio.unifesp.br/handle/11600/33007
dc.identifier10.1042/CS20090554
dc.identifierWOS:000284130000003
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/4023634
dc.description.abstractAngII (angiotensin II), ACE (angiotensin I-converting enzyme) and the AT(1) receptor (AngII type I receptor) are associated with the inflammatory process and microvascular dysfunction of AKI (acute kidney injury) induced by renal I/R (ischaemia/reperfusion). However, Ang-(1-7) [angiotensin-(1-7)], ACE2 (angiotensin I-converting enzyme 2) and the Mas receptor also play a role in renal disease models. Therefore, in the present study, we have examined the renal profile of Ang-(1-7), ACE2 and the Mas receptor in renal I/R and compared them with that of AngII, ACE and the AT(1) receptor. Male Wistar rats were submitted to left nephrectomy and ischaemia (45 min) followed by reperfusion (2 or 4 h) in the right kidney. At 4 h of reperfusion, renal AngII was increased (P < 0.01) and renal Ang-(1-7) was decreased substantially (P < 0.05), although plasma levels of both angiotensins were unchanged. in addition, renal I/R decreased the renal mRNA expression of renin (P < 0.05), AT(1) receptors (P < 0.001) and ACE2 (P < 0.05). At 2 and 4 h of reperfusion, renal ACE activity was reduced (P < 0.05). On the other hand, renal expression of the Mas receptor was greatly increased at 4 h of reperfusion (P < 0.01), which was confirmed by immunohistochemical and Western blot analysis. in conclusion, increased renal expression of the Mas receptor associated with changes in the RAS (renin-angiotensin-system)-related peptidases support an important role for the ACE2 Ang-(1-7) Mas axis in AKI.
dc.languageeng
dc.publisherPortland Press Ltd
dc.relationClinical Science
dc.rightsAcesso aberto
dc.subjectacute kidney injury
dc.subjectangiotensin I-converting enzyme (ACE)
dc.subjectangiotensin I-converting enzyme 2 (ACE2)
dc.subjectangiotensin-(1-7) [Ang-(1-7)]
dc.subjectangiotensin II (AngII)
dc.subjectMas receptor
dc.titleACE2-angiotensin-(1-7)-Mas axis in renal ischaemia/reperfusion injury in rats
dc.typeArtigo


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