Phytochemical analysis of hydroethanolic extract of turnera diffusa willd and evaluation of its effects on astrocyte cell death
Análise fitoquímica do extrato hidroetanólico de Turnera diffusa Willd e avaliação de seus efeitos na morte de astrócitos
dc.creator | Bezerra, Andreia Gomes [UNIFESP] | |
dc.creator | Negri, Giuseppina [UNIFESP] | |
dc.creator | Duarte-Almeida, Joaquim Mauricio | |
dc.creator | Smaili, Soraya Soubhi [UNIFESP] | |
dc.creator | Carlini, Elisaldo Araujo [UNIFESP] | |
dc.date.accessioned | 2019-01-21T10:29:46Z | |
dc.date.accessioned | 2022-10-07T20:49:48Z | |
dc.date.available | 2019-01-21T10:29:46Z | |
dc.date.available | 2022-10-07T20:49:48Z | |
dc.date.created | 2019-01-21T10:29:46Z | |
dc.date.issued | 2016 | |
dc.identifier | Einstein-Sao Paulo. Sao paulo sp, v. 14, n. 1, p. 56-63, 2016. | |
dc.identifier | 1679-4508 | |
dc.identifier | http://repositorio.unifesp.br/handle/11600/49379 | |
dc.identifier | S1679-45082016000100056.pdf | |
dc.identifier | S1679-45082016000100056 | |
dc.identifier | 10.1590/S1679-45082016AO3386 | |
dc.identifier | WOS:000385715800012 | |
dc.identifier.uri | http://repositorioslatinoamericanos.uchile.cl/handle/2250/4023531 | |
dc.description.abstract | Objective: To evaluate the phytochemical composition of hydroethanolic extracts from powdered aerial parts of Turnera diffusa Willd (Turneraceae | |
dc.description.abstract | T. diffusa), as well as its toxicity in astrocytes. Methods: Chemical analyses of hydroethanolic extract from powdered aerial parts of T. diffusa were carried out using HPLC-DAD-ESI-MS/MS. In vitro assays using astrocytes culture were performed to evaluate cell death. Results: Flavone-C, O-diglycosides, such as, luteolin-8-C-[6-deoxy-2-O-rhamnosyl]-xylo-hexos-3-uloside, apigenin-8-C-[ 6-deoxy-2-O-rhamnosyl]-xylo-hexos-3-uloside and apigenin-7-O-6"-p-coumaroylglucoside were the main compounds found in this hydroethanolic extract. Concentration time-effect demonstrated the toxicity of this extract at a concentration of 1,000 mu g/mL in astrocyte culture, after 6 and 24 hours of incubation. Conclusion: In phytochemical analyses, important antioxidants (mainly flavonoids) were observed. T. diffusa extracts presented cytotoxic effect in high concentrations, leading to increased cell death in astrocyte culture. | |
dc.language | eng | |
dc.publisher | Elsevier Science Bv | |
dc.relation | Einstein-Sao Paulo | |
dc.rights | Acesso aberto | |
dc.subject | Cognition/Drug Effects | |
dc.subject | Plant Extracts/Toxicity | |
dc.subject | Protective Agents/Toxicity | |
dc.subject | Antioxidants | |
dc.subject | Cell Death/Drug EffectsPerformance Liquid-Chromatography | |
dc.subject | Quadrupole Mass-Spectrometry | |
dc.subject | Ultraviolet Uv Radiation | |
dc.subject | In-Vitro Model | |
dc.subject | Phenolic-Compounds | |
dc.subject | Electrospray-Ionization | |
dc.subject | Antioxidant Properties | |
dc.subject | Acid-Derivatives | |
dc.subject | Oxidative Stress | |
dc.subject | Quality-Control | |
dc.title | Phytochemical analysis of hydroethanolic extract of turnera diffusa willd and evaluation of its effects on astrocyte cell death | |
dc.title | Análise fitoquímica do extrato hidroetanólico de Turnera diffusa Willd e avaliação de seus efeitos na morte de astrócitos | |
dc.type | Artigo |