Amitriptyline eliminates calculi through urinary tract smooth muscle relaxation

dc.contributorUniversidade Federal de São Paulo (UNIFESP)
dc.contributorSao Teodoro Vet Hosp
dc.creatorAchar, Eduardo [UNIFESP]
dc.creatorAchar, Rosi Aparecida Nunes [UNIFESP]
dc.creatorPaiva, Therezinha Bandiera [UNIFESP]
dc.creatorCampos, Alexandre Holthausen [UNIFESP]
dc.creatorSchor, Nestor [UNIFESP]
dc.date.accessioned2016-01-24T12:34:03Z
dc.date.accessioned2022-10-07T20:45:26Z
dc.date.available2016-01-24T12:34:03Z
dc.date.available2022-10-07T20:45:26Z
dc.date.created2016-01-24T12:34:03Z
dc.date.issued2003-10-01
dc.identifierKidney International. Malden: Blackwell Publishing Inc, v. 64, n. 4, p. 1356-1364, 2003.
dc.identifier0085-2538
dc.identifierhttp://repositorio.unifesp.br/handle/11600/27417
dc.identifier10.1046/j.1523-1755.2003.00222.x
dc.identifierWOS:000185226200024
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/4022394
dc.description.abstractBackground. We investigated the effects of amitriptyline in the urinary tract smooth muscle and urolithiasis.Methods. Cats presenting with obstructive acute renal failure (ARF) received amitriptyline, and renal function and survival rates were analyzed. Isometric contractions and membrane potentials of rat, pig, or human isolated urinary tract smooth muscle were recorded in the presence or absence of amitriptyline.Results. Twenty cats with obstructive ARF caused by urethral plugs received amitriptyline. in all cases, plugs were completely eliminated, and renal function returned to normal, with a 100% survival rate in the follow-up. Amitriptyline produced potent relaxations in rat urethral strips, accompanied by significant reductions in urethral ring membrane potential. This effect was prevented by pretreatment of urethral rings with 4-aminopyridine (4-AP), a voltage-dependent potassium channel blocker. Amitriptyline abolished in a reversible manner acetylcholine-, bradykinin-, and KCl-induced contractions in rat isolated bladder, and this effect was also prevented by 4-AP. of interest, spontaneous and KCl-induced contractions of pig and human isolated ureter were also blocked by amitriptyline.Conclusion. Our results indicate that amitriptyline is an effective and potent relaxant of urinary tract smooth muscle and this effect is mediated by opening of voltage dependent-potassium channels. We suggest that amitriptyline administration may help to promote elimination of urinary calculi.
dc.languageeng
dc.publisherBlackwell Publishing Inc
dc.relationKidney International
dc.rightsAcesso aberto
dc.subjectamitriptyline
dc.subjecturinary tract smooth muscle
dc.subjectvoltage-dependent potassium channel
dc.subjectrelaxation
dc.subjectobstructive acute renal failure
dc.subjecturolithiasis
dc.titleAmitriptyline eliminates calculi through urinary tract smooth muscle relaxation
dc.typeArtigo


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