Impact of Hydroxyurea on Anthropometry and Serum 25-Hydroxyvitamin D Among Children With Sickle Cell Disease

dc.creatorAdegoke, Samuel Ademola [UNIFESP]
dc.creatorBraga, Josefina Aparecida Pellegrini [UNIFESP]
dc.creatorAdekile, Adekunle D.
dc.creatorFigueiredo, Maria Stella [UNIFESP]
dc.date.accessioned2020-07-20T16:30:53Z
dc.date.accessioned2022-10-07T20:44:51Z
dc.date.available2020-07-20T16:30:53Z
dc.date.available2022-10-07T20:44:51Z
dc.date.created2020-07-20T16:30:53Z
dc.date.issued2018
dc.identifierJournal Of Pediatric Hematology Oncology. Philadelphia, v. 40, n. 4, p. E243-E247, 2018.
dc.identifier1077-4114
dc.identifierhttps://repositorio.unifesp.br/handle/11600/55573
dc.identifier10.1097/MPH.0000000000001002
dc.identifierWOS:000431106500011
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/4022233
dc.description.abstractObjective: To evaluate the impact of hydroxyurea (HU) on nutritional status and serum 25-hydroxyvitamin D (25-OHD) of children with sickle cell disease (SCD). Design: Anthropometry and serum 25-OHD were determined in 98 children with SCD, comprising of 68 in HU-group and 30 in HU-naive group. Results: Underweight was more common among HU-naive group (33.3% vs. 10.3%, P=0.009), while 79.4% of HU-group against 56.7% HU-naive had normal body mass index percentile for age and sex, P=0.028. None of the HU-group compared with 13.3% of the HU-naive had severe vitamin D deficiency, P=0.002. The mean 25-OHD of the HU-group was also higher (24.11.2 vs. 19.1 +/- 9.8ng/mL, P=0.007). Conclusions: HU possibly ameliorate growth retardation and vitamin D deficiency in children with SCD.
dc.languageeng
dc.publisherLippincott Williams & Wilkins
dc.relationJournal Of Pediatric Hematology Oncology
dc.rightsAcesso restrito
dc.subjectfat percentage
dc.subjectgrowth
dc.subjecthydroxyurea
dc.subject25-hydroxyvitamin D
dc.subjectnutritional status
dc.titleImpact of Hydroxyurea on Anthropometry and Serum 25-Hydroxyvitamin D Among Children With Sickle Cell Disease
dc.typeArtigo


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