Effect of ganglioside (GM1) on memory in senescent rats

dc.contributorUniversidade Federal de São Paulo (UNIFESP)
dc.contributorUniversidade de São Paulo (USP)
dc.contributorFAC CIENCIAS MED SANTA CASA SAO PAULO
dc.creatorSilva, Regina Helena da [UNIFESP]
dc.creatorFelicio, Luciano Freitas
dc.creatorNasello, Antonia Gladys
dc.creatorVital, Maria Aparecida Barbato Frazao [UNIFESP]
dc.creatorFrussa-Filho, Roberto [UNIFESP]
dc.date.accessioned2018-06-18T11:15:18Z
dc.date.accessioned2022-10-07T20:40:16Z
dc.date.available2018-06-18T11:15:18Z
dc.date.available2022-10-07T20:40:16Z
dc.date.created2018-06-18T11:15:18Z
dc.date.issued1996-07-01
dc.identifierNeurobiology Of Aging. New York: Elsevier Science Inc, v. 17, n. 4, p. 583-586, 1996.
dc.identifier0197-4580
dc.identifierhttp://repositorio.unifesp.br/11600/45009
dc.identifier10.1016/0197-4580(96)00065-6
dc.identifierWOS:A1996UZ20600012
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/4020927
dc.description.abstractMonosialoganglioside GM1 (GM1) has been found to alleviate genetic and lesion-induced memory deficits. The purpose of this study was to investigate the effects of 7-day treatment with GM1 (50 mg/kg IF) on acquisition and retention performance of senescent rats in a passive avoidance situation. Saline-treated old rats showed a decreased performance in acquisition and retention tests as compared to saline-treated adult rats. GM1 improved both acquisition and retention performance of old animals, and there was no significant difference between GM1-treated old rats and saline-treated adult rats. These data suggest that GM1 treatment can improve memory deficits in intact senescent animals.
dc.languageeng
dc.publisherElsevier B.V.
dc.relationNeurobiology Of Aging
dc.rightshttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dc.rightsAcesso restrito
dc.subjectmonosialoganglioside (GM1)
dc.subjectmemory
dc.subjectpassive avoidance
dc.titleEffect of ganglioside (GM1) on memory in senescent rats
dc.typeArtigo


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