The action of CGRP and SP on cultured skin fibroblasts

dc.contributorUniversidade Federal de São Paulo (UNIFESP)
dc.contributorUniv Estadual Santa Cruz
dc.creatorHochman, Bernardo [UNIFESP]
dc.creatorTucci-Viegas, Vanina Monique [UNIFESP]
dc.creatorMonteiro, Paola K. P. [UNIFESP]
dc.creatorFranca, Jeronimo Pereira de [UNIFESP]
dc.creatorGaiba, Silvana [UNIFESP]
dc.creatorFerreira, Lydia Masako [UNIFESP]
dc.date.accessioned2016-01-24T14:37:30Z
dc.date.accessioned2022-10-07T20:40:10Z
dc.date.available2016-01-24T14:37:30Z
dc.date.available2022-10-07T20:40:10Z
dc.date.created2016-01-24T14:37:30Z
dc.date.issued2014-07-01
dc.identifierCentral European Journal of Biology. Warsaw: de Gruyter Open Ltd, v. 9, n. 7, p. 717-726, 2014.
dc.identifier1895-104X
dc.identifierhttp://repositorio.unifesp.br/handle/11600/37915
dc.identifierWOS000335495900007.pdf
dc.identifier10.2478/s11535-014-0301-6
dc.identifierWOS:000335495900007
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/4020906
dc.description.abstractCalcitonin gene-related peptide (CGRP) is the most abundant neuropeptide in the skin, followed by substance P (SP), vasoactive intestinal peptide (VIP), and other neuropeptides in smaller amounts. the proliferative effect of neuropeptides on fibroblasts may affect wound healing and may be associated with hyperproliferative skin and mesenchymal disorders. Understanding the neuropeptidergic action on fibroblasts may provide relevant information to a deeper comprehension of the healing process. This study reviews the action of the main neuropeptides, CGRP and SP, on cultured human skin fibroblasts.A systematic literature search was conducted on Medline and Web of Science databases on December 21, 2013.A total of 74 articles were retrieved using the proposed search strategies and 3 were found in the references section of the selected articles. Thirteen of the retrieved articles studied the action of CGRP and SP on cultured human skin fibroblasts, 12 of which related to SP and 1 related to both CGRP and SP.Only one study was retrieved about the action of both CGRP and SP on cultured human skin fibroblasts. Further studies are necessary to investigate CGRP on skin fibroblasts and its role in the fibroplasia phase of wound healing.
dc.languageeng
dc.publisherDe Gruyter Open Ltd
dc.relationCentral European Journal of Biology
dc.rightsAcesso aberto
dc.subjectCalcitonin gene-related peptide
dc.subjectSubstance P
dc.subjectFibroblasts
dc.subjectWound healing
dc.subjectSkin
dc.titleThe action of CGRP and SP on cultured skin fibroblasts
dc.typeResenha


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