Effects of in vitro, acute and chronic treatment with fluoxetine on the sympathetic neurotransmission of rat vas deferens

dc.creatorPedroso, Shaista Poppe [UNIFESP]
dc.creatorde Souza, Bruno Palmieri [UNIFESP]
dc.creatorJurkiewicz, Aron [UNIFESP]
dc.creatorJuriewicz, Neide H. [UNIFESP]
dc.creatorda Silva Junior, Edilson Dantas [UNIFESP]
dc.date.accessioned2020-07-17T14:02:48Z
dc.date.accessioned2022-10-07T20:37:23Z
dc.date.available2020-07-17T14:02:48Z
dc.date.available2022-10-07T20:37:23Z
dc.date.created2020-07-17T14:02:48Z
dc.date.issued2017
dc.identifierAutonomic Neuroscience-Basic & Clinical. Amsterdam, v. 203, p. 17-24, 2017.
dc.identifier1566-0702
dc.identifierhttps://repositorio.unifesp.br/handle/11600/55037
dc.identifier10.1016/j.autneu.2016.10.006
dc.identifierWOS:000397358100003
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/4020201
dc.description.abstractIt is described that fluoxetine treatment is able to induce ejaculatory disorders. However, the exact mechanism is still not fully understood. Therefore, this study was carried out to further evaluate the anti-ejaculatory effects of fluoxetine, using different approaches (in vitro or in vivo treatments), on the sympathetic neurotransmission of the rat vas deferens. Vas deferens from male Wistar rats were used to check the in vitro effects of fluoxetine 10(-6) M, 3.10(-6) M or 10(-5) M. Animals were also acutely (20 mg/kg, i.p. 4 h or 24 h) or chronically (10 mg/kg, i.p., 30 days) treated with fluoxetine or drug-free vehicle. The vas deferens from non -treated and treated animals were isolated and mounted in an isolated organ bath for the study of the contractions induced by adrenergic agonists, tyramine, 5-HT, Ca2+ or electrical field stimulation. In vitro or acute treatment with fluoxetine decreased the contraction induced by agonists, Ca2+ or electrical field stimulation. The chronic treatment with fluoxetine decreased the contractions induced agonists, tyramine or Ca2+, but did not modify the contractions induced by electrical field stimulation. We have shown that in vitro or in vivo fluoxetine treatment is able to alter the sympathetic neurotransmission of the rat vas deferens which could be related to alterations in the calcium signalling. (C) 2016 Elsevier B.V. All rights reserved.
dc.languageeng
dc.publisherElsevier Science Bv
dc.relationAutonomic Neuroscience-Basic & Clinical
dc.rightsAcesso restrito
dc.subjectFluoxetine
dc.subjectVas deferens
dc.subjectSympathetic neurotransmission
dc.subjectIn vitro or in vivo treatments
dc.titleEffects of in vitro, acute and chronic treatment with fluoxetine on the sympathetic neurotransmission of rat vas deferens
dc.typeArtigo


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