dc.creatorIzumi, Suelem [UNIFESP]
dc.creatorRibeiro-Filho, Fernando F.
dc.creatorCarneiro, Glaucia [UNIFESP]
dc.creatorTogeiro, Sania M. [UNIFESP]
dc.creatorTufik, Sergio [UNIFESP]
dc.creatorZanella, Maria T. [UNIFESP]
dc.date.accessioned2019-01-21T10:30:01Z
dc.date.accessioned2022-10-07T20:36:53Z
dc.date.available2019-01-21T10:30:01Z
dc.date.available2022-10-07T20:36:53Z
dc.date.created2019-01-21T10:30:01Z
dc.date.issued2016
dc.identifierJournal Of Clinical Sleep Medicine. Westchester, v. 12, n. 4, p. 487-493, 2016.
dc.identifier1550-9389
dc.identifierhttp://repositorio.unifesp.br/handle/11600/49538
dc.identifier10.5664/jcsm.5672
dc.identifierWOS:000374140000005
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/4020092
dc.description.abstractStudy Objectives: This study examined insulin-like growth factor-1 (IGF-1) production and its association with the metabolic syndrome (MS) in men with obstructive sleep apnea (OSA). Methods: In total, 47 overweight and obese men who had been referred for suspected OSA underwent polysomnography and were classified based on the apnea-hypopnea index (AHI) into three groups: no OSA, < 5 events/h (n = 11)
dc.description.abstractmild OSA, >= 5 to < 15 events/h (n = 8)
dc.description.abstractand moderate-severe OSA, >= 15 events/h (n = 28). The assessment of the somatotropic axis function included IGF-1 measurement. MS was diagnosed according to the National Cholesterol Education Program guidelines. Results: IGF-1 level in the moderate-severe OSA group was lower than in the no-OSA group (156.8 +/- 54.3 mu g/L versus 225.5 +/- 80.5 mu g/L
dc.description.abstractp = 0.013). IGF-1 level was negatively correlated with body mass index, waist circumference (WC), AHI, and sleep duration with oxygen (O-2) saturation < 90% and positively correlated with the average and minimum O-2 saturation (p = 0.027). In a multivariable linear regression, considering WC and minimum O-2 saturation as independent variables, only the minimum O-2 saturation was a predictor of low IGF-1 levels. The proportions of patients with MS were different between the three groups (18.2% in no OSA
dc.description.abstract25% in mild OSA, and 57.1% in moderate-severe OSA
dc.description.abstractp = 0.047). Furthermore, in the lowest tertile of IGF-1 value, 66.7% of patients were affected by MS (p = 0.049). Hemoglobin (Hb)A1c correlated negatively with the minimum O-2 saturation and IGF-1 levels. However, in multivariable linear regression only IGF-1 levels were a predictor of HbA1c levels. Conclusion: The occurrence of OSA is associated with a reduction in IGF-1 levels. IGF-1 alterations in OSA also seem to be associated with a higher prevalence of MS.
dc.languageeng
dc.publisherAmer acad sleep medicine
dc.relationJournal Of Clinical Sleep Medicine
dc.rightsAcesso restrito
dc.subjectGh/Igf-1 Axis
dc.subjectIgf-1
dc.subjectInsulin-Like Growth Factor-1
dc.subjectMetabolic Syndrome
dc.subjectObstructive Sleep ApneaGrowth-Factor-I
dc.subjectOnset Gh Deficiency
dc.subjectHypopituitary Patients
dc.subjectGeneral-Population
dc.subjectInsulin-Resistance
dc.subjectHormone Secretion
dc.subjectObese-Patients
dc.subjectKims Analysis
dc.subjectPrevalence
dc.subjectAdults
dc.titleIgf-1 levels are inversely associated with metabolic syndrome in obstructive sleep apnea
dc.typeArtigo


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