Detection of Cerebral Vasculopathy by Transcranial Doppler in Children With Neurofibromatosis Type 1

dc.creatorSagica Fernandes Paschoal, Joelma Karin [UNIFESP]
dc.creatorPaschoal, Fernando Mendes, Jr.
dc.creatorde Lima, Fernanda Teresa [UNIFESP]
dc.creatorPinho, Ricardo Silva [UNIFESP]
dc.creatorPereira Vilanova, Luiz Celso [UNIFESP]
dc.creatorBor-Seng-Shu, Edson
dc.creatorMasruha, Marcelo Rodrigues [UNIFESP]
dc.date.accessioned2020-08-21T17:00:18Z
dc.date.accessioned2022-10-07T20:36:09Z
dc.date.available2020-08-21T17:00:18Z
dc.date.available2022-10-07T20:36:09Z
dc.date.created2020-08-21T17:00:18Z
dc.date.issued2016
dc.identifierJournal Of Child Neurology. Thousand Oaks, v. 31, n. 3, p. 351-356, 2016.
dc.identifier0883-0738
dc.identifierhttps://repositorio.unifesp.br/handle/11600/57931
dc.identifier10.1177/0883073815595080
dc.identifierWOS:000370429700013
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/4019939
dc.description.abstractNeurofibromatosis type 1 is characterized by nerve sheath neurofibromas associated with a number of additional clinical features, including cerebrovascular disease. The aim of this study was to use transcranial Doppler as a screening method for identifying cerebral vasculopathy in children with neurofibromatosis type 1. Forty children with neurofibromatosis type 1, aged 5 to 18 years old, were examined by transcranial Doppler. Patients presenting with hemodynamic features of arterial stenosis/occlusion on transcranial Doppler underwent magnetic resonance angiography to confirm the findings. Magnetic resonance angiography was performed on 4 children who exhibited a transcranial Doppler hemodynamic pattern indicative of cerebral vasculopathy. Among these cases, 2 presented internal carotid artery stenosis/occlusion, 1 had bilateral middle cerebral artery stenosis, and 1 presented a normal magnetic resonance angiography result. Transcranial Doppler can be used routinely in the investigation of cerebrovascular disease in neurofibromatosis type 1 patients, where magnetic resonance angiography can be subsequently applied to confirm the diagnosis, further contributing to the prevention of cerebrovascular events.
dc.languageeng
dc.publisherSage Publications Inc
dc.relationJournal Of Child Neurology
dc.rightsAcesso restrito
dc.subjecttranscranial Doppler
dc.subjectneurofibromatosis
dc.subjectcerebrovascular disease
dc.titleDetection of Cerebral Vasculopathy by Transcranial Doppler in Children With Neurofibromatosis Type 1
dc.typeArtigo


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