SODIUM DICLOFENAC INHIBITS HYPERTHERMIA-INDUCED BY PARADOXICAL SLEEP-DEPRIVATION - the POSSIBLE PARTICIPATION of PROSTAGLANDINS

dc.contributorUniversidade Federal de São Paulo (UNIFESP)
dc.creatorSeabra, MDV
dc.creatorTufik, S.
dc.date.accessioned2016-01-24T11:40:14Z
dc.date.accessioned2022-10-07T20:34:50Z
dc.date.available2016-01-24T11:40:14Z
dc.date.available2022-10-07T20:34:50Z
dc.date.created2016-01-24T11:40:14Z
dc.date.issued1993-11-01
dc.identifierPhysiology & Behavior. Oxford: Pergamon-Elsevier B.V., v. 54, n. 5, p. 923-926, 1993.
dc.identifier0031-9384
dc.identifierhttp://repositorio.unifesp.br/handle/11600/25358
dc.identifier10.1016/0031-9384(93)90303-W
dc.identifierWOS:A1993MB62800015
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/4019676
dc.description.abstractSodium diclofenac inhibits hyperthermia induced by paradoxical sleep deprivation (PSD), which suggests the participation of prostaglandins. the temperature of paradoxical sleep-deprived rats increased from the first to the fourth day of deprivation. This hyperthermia was blocked on the second, third, and fourth days by daily administration, twice a day, of 10 mg/kg of sodium diclofenac, a potent prostaglandin synthesis inhibitor. in the dose of 10 mg/kg, a decrease of temperature was observed only on the second and third days of PSD. These data suggest the participation of prostaglandins in modulating the increase in temperature during PSD.
dc.languageeng
dc.publisherElsevier B.V.
dc.relationPhysiology & Behavior
dc.rightshttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dc.rightsAcesso restrito
dc.subjectPROSTAGLANDINS
dc.subjectPARADOXICAL SLEEP DEPRIVATION
dc.subjectSODIUM DICLOFENAC
dc.subjectINTERLEUKIN-1
dc.subjectTHERMOREGULATION
dc.titleSODIUM DICLOFENAC INHIBITS HYPERTHERMIA-INDUCED BY PARADOXICAL SLEEP-DEPRIVATION - the POSSIBLE PARTICIPATION of PROSTAGLANDINS
dc.typeArtigo


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