The C-terminus of murine S100A9 inhibits hyperalgesia and edema induced by jararhagin

dc.contributorButantan Inst
dc.contributorUniversidade Federal de São Paulo (UNIFESP)
dc.creatorDale, C. S.
dc.creatorGoncalves, LRC
dc.creatorJuliano, L.
dc.creatorJuliano, M. A.
dc.creatorSilva, AMM da
dc.creatorGiorgi, R.
dc.date.accessioned2016-01-24T12:34:12Z
dc.date.accessioned2022-10-07T20:33:11Z
dc.date.available2016-01-24T12:34:12Z
dc.date.available2022-10-07T20:33:11Z
dc.date.created2016-01-24T12:34:12Z
dc.date.issued2004-01-01
dc.identifierPeptides. New York: Elsevier B.V., v. 25, n. 1, p. 81-89, 2004.
dc.identifier0196-9781
dc.identifierhttp://repositorio.unifesp.br/handle/11600/27547
dc.identifier10.1016/j.peptides.2003.12.008
dc.identifierWOS:000220267900011
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/4019351
dc.description.abstractThe effect of a synthetic peptide (H-92-G(110)) identical to the C-terminus of murine S100A9 (mS100A9p) was investigated on hyperalgesia and edema induced by either jararhagin or papain in the rat paw. mS100A9p not only reverted hyperalgesia and edema induced by jararhagin, but also the highest concentration induced antinociception. Hemorrhage induced by jararhagin and its hydrolytic activity were inhibited by mS100A9p. These data suggest that mS100A9p might block jararhagin-induced hyperalgesia and edema by inhibiting jararhagin catalytic activity, since papain-induced hyperalgesia and edema were not inhibited by mS100A9p. (C) 2004 Elsevier Inc. All rights reserved.
dc.languageeng
dc.publisherElsevier B.V.
dc.relationPeptides
dc.rightshttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dc.rightsAcesso restrito
dc.subjecthyperalgesia
dc.subjectedema
dc.subjectjararhagin
dc.subjectpapain
dc.subjectMRP-14
dc.subjectS100A9
dc.titleThe C-terminus of murine S100A9 inhibits hyperalgesia and edema induced by jararhagin
dc.typeArtigo


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