Dopamine Transporter Imaging Using Tc-99m-TRODAT-1 SPECT in Parkinson's Disease

dc.contributorUniversidade de São Paulo (USP)
dc.contributorUniversidade Federal de São Paulo (UNIFESP)
dc.contributorHosp Israelita Albert Einstein
dc.creatorBor-Seng-Shu, Edson
dc.creatorFelício, André Carvalho [UNIFESP]
dc.creatorBraga-Neto, Pedro [UNIFESP]
dc.creatorBatista, Ilza Rosa [UNIFESP]
dc.creatorPaiva, Wellingson Silva
dc.creatorAndrade, Daniel Ciampi de
dc.creatorTeixeira, Manoel Jacobsen
dc.creatorFranco de Andrade, Luiz Augusto
dc.creatorBarsottini, Orlando Graziani Povoas [UNIFESP]
dc.creatorShih, Ming Chi
dc.creatorBressan, Rodrigo Affonseca [UNIFESP]
dc.creatorFerraz, Henrique Ballalai [UNIFESP]
dc.date.accessioned2018-06-18T11:03:58Z
dc.date.accessioned2022-10-07T20:31:28Z
dc.date.available2018-06-18T11:03:58Z
dc.date.available2022-10-07T20:31:28Z
dc.date.created2018-06-18T11:03:58Z
dc.date.issued2014-08-11
dc.identifierMedical Science Monitor. Smithtown: Int Scientific Literature, Inc, v. 20, p. 1413-1418, 2014.
dc.identifier1643-3750
dc.identifierhttp://repositorio.unifesp.br/11600/44876
dc.identifier10.12659/MSM.890522
dc.identifierWOS:000341005300001
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/4019033
dc.description.abstractBackground: Although the decrease in striatal dopamine transporter (DAT) density has been described in North American, European, and Asian Parkinson's disease (PD) patients, studies on this issue are required in the rest of the world. This study examined the diagnostic utility of DAT imaging in Brazilian PD patients.Material/Methods: Twenty PD patients (13 males, 7 females, median age: 62 years, median age at disease onset: 56 years, median disease duration: 5 years, and median UPDRS-III score: 29) and 9 age-and sex-matched healthy subjects underwent single-photon emission computerized tomography (SPECT) using Tc-99m-TRODAT-1.Results: PD patients showed a significant decrease in the striatum, caudate nucleus, and putamen DAT densities compared with data from healthy subjects. Striatal Tc-99m-TRODAT-1 bindings had the highest diagnostic accuracy compared to those estimates from caudate nucleus and putamen. For the diagnosis of PD, a striatal Tc-99m-TRODAT-1 binding cut-off value of 0.90 was associated with a sensitivity of 100% and a specificity of 89%. There was no significant difference between striatal Tc-99m-TRODAT-1 binding values provided by different readers, contrary to Tc-99m-TRODAT-1 binding estimates in the caudate nucleus.Conclusions: Striatal DAT imaging using Tc-99m-TRODAT-1 can be considered a marker for differentiating PD patients from healthy individuals, with a good interobserver reproducibility.
dc.languageeng
dc.publisherInt Scientific Literature, Inc
dc.relationMedical Science Monitor
dc.rightsAcesso aberto
dc.subjectMolecular Imaging
dc.subjectParkinson Disease - radionuclide imaging
dc.subjectTomography, Emission-Computed, Single-Photon
dc.titleDopamine Transporter Imaging Using Tc-99m-TRODAT-1 SPECT in Parkinson's Disease
dc.typeArtigo


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