Can morphine interfere in the healing process during chronic stress?

dc.contributorUniversidade Federal de São Paulo (UNIFESP)
dc.creatorEgydio, F. [UNIFESP]
dc.creatorRuiz, F. S. [UNIFESP]
dc.creatorTomimori, J. [UNIFESP]
dc.creatorTufik, Sergio [UNIFESP]
dc.creatorAndersen, Monica Levy [UNIFESP]
dc.date.accessioned2016-01-24T14:27:30Z
dc.date.accessioned2022-10-07T20:31:00Z
dc.date.available2016-01-24T14:27:30Z
dc.date.available2022-10-07T20:31:00Z
dc.date.created2016-01-24T14:27:30Z
dc.date.issued2012-08-01
dc.identifierArchives of Dermatological Research. New York: Springer, v. 304, n. 6, p. 413-420, 2012.
dc.identifier0340-3696
dc.identifierhttp://repositorio.unifesp.br/handle/11600/35120
dc.identifier10.1007/s00403-012-1261-1
dc.identifierWOS:000306695300001
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/4018954
dc.description.abstractTechnological advances, constant pressure, increased qualified demand, and other daily activities present in modern society result in increasingly stressful living conditions for the population. in the short term, the release of stress-related hormones can play a key role in the survival of an organism. However, it is well known that chronic exposure to cortisol can lead to many adverse effects. Several findings show immunological changes in response to chronic exposure to cortisol, in particular in skin integrity, which may interfere with the healing process. Morphine is an immunosuppressive drug, and when it is used chronically, it can lead to an increased incidence of infections and a delay in the healing process. the importance of opiates as analgesics in the medical setting is indisputable. However, there are a limited number of studies in this field. These investigations can provide further understanding of the mechanisms involved in the healing process in morphine-dependent individuals under chronic stress, which is a common condition in modern society. Furthermore, medical prescriptions of opiates are common among terminal patients, who frequently develop decubitus ulcers and bacterial infections. This review is aimed to provide a concise analysis of effects of morphine and stress on the healing process.
dc.languageeng
dc.publisherSpringer
dc.relationArchives of Dermatological Research
dc.rightshttp://www.springer.com/open+access/authors+rights?SGWID=0-176704-12-683201-0
dc.rightsAcesso restrito
dc.subjectWound healing
dc.subjectStress
dc.subjectSkin
dc.subjectMorphine
dc.subjectCortisol
dc.subjectSleep deprivation
dc.titleCan morphine interfere in the healing process during chronic stress?
dc.typeResenha


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