Artigo de Periódico
Heterogenic colonization patterns by Leptospira interrogans in Rattus norvegicus from urban slums.
Fecha
2015Registro en:
1678-4405
v.46, n.4, p.1161-1164
Autor
Santos, Ana Amélia Nunes
Figueira, Cláudio Pereira
Reis, Mitermayer Galvão dos
Costa, Federico
Ristow, Paula Carvalhal Lage von Buettner
Institución
Resumen
We evaluated the renal colonization by
Leptospira interrogans in Rattus norvegicus
(rats), as it is the major natural reservoir of urban leptospirosis. We caught 72 R. norvegicus, out of which 32 were found to be positive for L. interrogans by immunofluorescence assay. From these rats, we selected 17 and divided them into six groups based on the mass-age/sex. We performed the immunohistochemistry test against L. interrogans in the kidney sections of the rats and systematically counted the colonized tubules (CTs) in 20 fields. The proportion of positive fields varied from 5% to 95%. The number of CTs in 20 fields varied from 0.5 to 85.5. These differences were not related to age or sex of
the animals. The characterization of leptospiral colonization patterns in the natural reservoirs is important to better understand the host-pathogen interactions in leptospirosis.