dc.creator | Xia, Tianli | |
dc.creator | O'Hara, Andrea | |
dc.creator | Araújo, Iguaracyra Barreto de Oliveira | |
dc.creator | Barreto, José Henrique Silva | |
dc.creator | Carvalho, Eny | |
dc.creator | Sapucaia, Jose Bahia | |
dc.creator | Luz, Estela | |
dc.creator | Pedroso, Celia | |
dc.creator | Brites, Carlos | |
dc.creator | Ramos, Juan Carlos | |
dc.creator | Manrique, Michele | |
dc.creator | Toomey, Ngoc L. | |
dc.creator | Dittmer, Dirk P. | |
dc.creator | Harrington Junior, William J. | |
dc.creator | Xia, Tianli | |
dc.creator | O'Hara, Andrea | |
dc.creator | Araújo, Iguaracyra Barreto de Oliveira | |
dc.creator | Barreto, José Henrique Silva | |
dc.creator | Carvalho, Eny | |
dc.creator | Sapucaia, Jose Bahia | |
dc.creator | Luz, Estela | |
dc.creator | Pedroso, Celia | |
dc.creator | Brites, Carlos | |
dc.creator | Ramos, Juan Carlos | |
dc.creator | Manrique, Michele | |
dc.creator | Toomey, Ngoc L. | |
dc.creator | Dittmer, Dirk P. | |
dc.creator | Harrington Junior, William J. | |
dc.date.accessioned | 2022-10-07T18:54:35Z | |
dc.date.available | 2022-10-07T18:54:35Z | |
dc.date.issued | 2008 | |
dc.identifier | 0008-5472 | |
dc.identifier | http://repositorio.ufba.br/ri/handle/ri/14272 | |
dc.identifier | v. 68, n. 5 | |
dc.identifier.uri | http://repositorioslatinoamericanos.uchile.cl/handle/2250/4012575 | |
dc.description.abstract | EBV-encoded microRNAs (miRNAs) have been identified and their functions are being studied. The expression pattern of these miRNAs in clinical samples of EBV-associated non–Hodgkin's lymphomas is unknown. We analyzed five primary “endemic” pediatric Burkitt's lymphomas (BL), two acquired immunodeficiency syndrome (AIDS)-related type I latency BL lines, a type III latency line, three EBV+ primary effusion lymphomas (PEL), and three AIDS-related diffuse large B-cell lymphomas (DLBCL) for expression of EBV-encoded miRNAs. A markedly elevated expression of miRNA BHRF1-3 in type III relative to its parental type I BL line was found. Primary unmanipulated type I BLs and EBV+ PELs expressed high levels of BART2 miRNA, whereas DLBCLs expressed both BART2 and BHRF1-3 species. BHRF1-3 miRNA expression inversely correlated with levels of a putative cellular target, the IFN-inducible T-cell attracting chemokine CXCL-11/I-TAC, and suppression of this factor was reversed by transfection of an antisense oligo to the EBV miRNA BHRF1-3. EBV-encoded miRNAs are expressed in primary lymphomas classically linked to the virus and are associated with the viral latency status. Targeted suppression of CXCL-11/I-TAC by a viral-encoded miRNA may serve as an immunomodulatory mechanism in these tumors. | |
dc.language | en | |
dc.rights | Acesso Aberto | |
dc.source | http://dx.doi.org/10.1158/0008-5472.CAN-07-5126 | |
dc.subject | Lymphoma | |
dc.subject | EBV | |
dc.subject | MicroRNA | |
dc.subject | Latency | |
dc.subject | Burkitt's | |
dc.title | EBV microRNAs in primary lymphomas and targeting of CXCL-11 by ebv-mir-BHRF1-3 | |
dc.type | Artigo de Periódico | |