dc.creatorNascimento, M. C. F.
dc.creatorLeite Primo, Janeusa Rita
dc.creatorBittencourt, Achilea Candida Lisboa
dc.creatorSiqueira, I.
dc.creatorOliveira, M. de Fátima
dc.creatorNascimento, Roberto José Meyer
dc.creatorSchriefer, Nicolaus Albert Borges
dc.creatorSantos, S. B.
dc.creatorCarvalho Filho, Edgar Marcelino de
dc.creatorNascimento, M. C. F.
dc.creatorLeite Primo, Janeusa Rita
dc.creatorBittencourt, Achilea Candida Lisboa
dc.creatorSiqueira, I.
dc.creatorOliveira, M. de Fátima
dc.creatorNascimento, Roberto José Meyer
dc.creatorSchriefer, Nicolaus Albert Borges
dc.creatorSantos, S. B.
dc.creatorCarvalho Filho, Edgar Marcelino de
dc.date.accessioned2022-10-07T18:39:37Z
dc.date.available2022-10-07T18:39:37Z
dc.date.issued2009
dc.identifier0009-9104
dc.identifierhttp://repositorio.ufba.br/ri/handle/ri/13749
dc.identifierv. 156, n. 3
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/4011997
dc.description.abstractHuman T lymphotropic virus-type 1 (HTLV-1) is the causal agent of the HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP), adult T cell leukaemia/lymphoma and infective dermatitis associated with HTLV-1 (IDH). Over-production of proinflammatory cytokines and an increase in HTLV-1 proviral load are features of HAM/TSP, but the immunological basis of IDH has not been established. In addition to severe cutaneous manifestations, the importance of IDH relies on the observation that up to 30% of children with IDH develop HAM/TSP in childhood and adolescence. In this study we determined the immune response in patients with IDH measuring interleukin (IL)-4, IL-5, IL-10, interferon (IFN)-γ and tumour necrosis factor (TNF)-α levels as well as the HTLV-1 proviral load. Additionally, regulatory cytokines and anti-cytokines were added to cultures to evaluate the ability of these molecules to down-modulate TNF-α and IFN-γ synthesis. HTLV-1 carriers and patients with HAM/TSP served as controls. TNF-α and IFN-γ levels were higher in IDH than in HTLV-1 carriers. There was no difference in IFN-γ and TNF-α concentrations in IDH and HAM/TSP patients. There was a tendency for higher IL-4 mRNA expression and immunoglobulin E (IgE) levels in IDH than in HTLV-1 carriers, but the difference did not reach statistical significance. The HTLV-1 proviral load was significantly higher in IDH patients than in HTLV-1 carriers. IDH is characterized by an exaggerated Th1 immune response and high HTLV-1 proviral load. The similarities between the immunological response in patients with IDH and HAM/TSP and the high proviral load observed in IDH provide support that IDH is a risk factor for development of HAM/TSP.
dc.languageen
dc.rightsAcesso Aberto
dc.sourcehttp://dx.doi.org/10.1111/j.1365-2249.2008.03869.x
dc.subjectCytokines/interleukins
dc.subjectDermatological infections
dc.subjectHTLV-I/II
dc.titleInfective dermatitis has similar immunological features to human T lymphotropic virus-type 1-associated myelopathy/tropical spastic paraparesis
dc.typeArtigo de Periódico


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