dc.creator | Nascimento, M. C. F. | |
dc.creator | Leite Primo, Janeusa Rita | |
dc.creator | Bittencourt, Achilea Candida Lisboa | |
dc.creator | Siqueira, I. | |
dc.creator | Oliveira, M. de Fátima | |
dc.creator | Nascimento, Roberto José Meyer | |
dc.creator | Schriefer, Nicolaus Albert Borges | |
dc.creator | Santos, S. B. | |
dc.creator | Carvalho Filho, Edgar Marcelino de | |
dc.creator | Nascimento, M. C. F. | |
dc.creator | Leite Primo, Janeusa Rita | |
dc.creator | Bittencourt, Achilea Candida Lisboa | |
dc.creator | Siqueira, I. | |
dc.creator | Oliveira, M. de Fátima | |
dc.creator | Nascimento, Roberto José Meyer | |
dc.creator | Schriefer, Nicolaus Albert Borges | |
dc.creator | Santos, S. B. | |
dc.creator | Carvalho Filho, Edgar Marcelino de | |
dc.date.accessioned | 2022-10-07T18:39:37Z | |
dc.date.available | 2022-10-07T18:39:37Z | |
dc.date.issued | 2009 | |
dc.identifier | 0009-9104 | |
dc.identifier | http://repositorio.ufba.br/ri/handle/ri/13749 | |
dc.identifier | v. 156, n. 3 | |
dc.identifier.uri | http://repositorioslatinoamericanos.uchile.cl/handle/2250/4011997 | |
dc.description.abstract | Human T lymphotropic virus-type 1 (HTLV-1) is the causal agent of the HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP), adult T cell leukaemia/lymphoma and infective dermatitis associated with HTLV-1 (IDH). Over-production of proinflammatory cytokines and an increase in HTLV-1 proviral load are features of HAM/TSP, but the immunological basis of IDH has not been established. In addition to severe cutaneous manifestations, the importance of IDH relies on the observation that up to 30% of children with IDH develop HAM/TSP in childhood and adolescence. In this study we determined the immune response in patients with IDH measuring interleukin (IL)-4, IL-5, IL-10, interferon (IFN)-γ and tumour necrosis factor (TNF)-α levels as well as the HTLV-1 proviral load. Additionally, regulatory cytokines and anti-cytokines were added to cultures to evaluate the ability of these molecules to down-modulate TNF-α and IFN-γ synthesis. HTLV-1 carriers and patients with HAM/TSP served as controls. TNF-α and IFN-γ levels were higher in IDH than in HTLV-1 carriers. There was no difference in IFN-γ and TNF-α concentrations in IDH and HAM/TSP patients. There was a tendency for higher IL-4 mRNA expression and immunoglobulin E (IgE) levels in IDH than in HTLV-1 carriers, but the difference did not reach statistical significance. The HTLV-1 proviral load was significantly higher in IDH patients than in HTLV-1 carriers. IDH is characterized by an exaggerated Th1 immune response and high HTLV-1 proviral load. The similarities between the immunological response in patients with IDH and HAM/TSP and the high proviral load observed in IDH provide support that IDH is a risk factor for development of HAM/TSP. | |
dc.language | en | |
dc.rights | Acesso Aberto | |
dc.source | http://dx.doi.org/10.1111/j.1365-2249.2008.03869.x | |
dc.subject | Cytokines/interleukins | |
dc.subject | Dermatological infections | |
dc.subject | HTLV-I/II | |
dc.title | Infective dermatitis has similar immunological features to human T lymphotropic virus-type 1-associated myelopathy/tropical spastic paraparesis | |
dc.type | Artigo de Periódico | |