dc.creator | Moncayo, A. L. | |
dc.creator | Vaca-Martínez, Gioconda Maritza | |
dc.creator | Oviedo, G. | |
dc.creator | Workman, L. J. | |
dc.creator | Chico, M. E. | |
dc.creator | Platts-Mills, T. A. E. | |
dc.creator | Rodrigues, L. C. | |
dc.creator | Barreto, Mauricio Lima | |
dc.creator | Cooper, P. J. | |
dc.creator | Moncayo, A. L. | |
dc.creator | Vaca-Martínez, Gioconda Maritza | |
dc.creator | Oviedo, G. | |
dc.creator | Workman, L. J. | |
dc.creator | Chico, M. E. | |
dc.creator | Platts-Mills, T. A. E. | |
dc.creator | Rodrigues, L. C. | |
dc.creator | Barreto, Mauricio Lima | |
dc.creator | Cooper, P. J. | |
dc.date.accessioned | 2013-07-09T17:53:43Z | |
dc.date.accessioned | 2022-10-07T17:53:43Z | |
dc.date.available | 2013-07-09T17:53:43Z | |
dc.date.available | 2022-10-07T17:53:43Z | |
dc.date.created | 2013-07-09T17:53:43Z | |
dc.date.issued | 2013 | |
dc.identifier | 0954-7894 | |
dc.identifier | http://www.repositorio.ufba.br/ri/handle/ri/12159 | |
dc.identifier | v. 43, n. 1 | |
dc.identifier.uri | http://repositorioslatinoamericanos.uchile.cl/handle/2250/4010711 | |
dc.description.abstract | Background Most childhood asthma in poor populations in Latin America is not associated
with aeroallergen sensitization, an observation that could be explained by the attenuation
of atopy by chronic helminth infections or effects of age.
Objective To explore the effects of geohelminth infections and age on atopy, wheeze, and
the association between atopy and wheeze.
Methods A case-control study was done in 376 subjects (149 cases and 227 controls) aged
7–19 years living in rural communities in Ecuador. Wheeze cases, identified from a large
cross-sectional survey, had recent wheeze and controls were a random sample of those
without wheeze. Atopy was measured by the presence of allergen-specific IgE (asIgE) and
skin prick test (SPT) responses to house dust mite and cockroach. Geohelminth infections
were measured in stools and anti-Ascaris IgE in plasma.
Results The fraction of recent wheeze attributable to anti-Ascaris IgE was 45.9%, while
those for SPT and asIgE were 10.0% and 10.5% respectively. The association between
atopy and wheeze was greater in adolescents than children. Although Anti-Ascaris IgE
was strongly associated with wheeze (adj. OR 2.24 (95% CI 1.33–3.78, P = 0.003) and with
asIgE (adj. OR 5.34, 95% CI 2.49–11.45, P < 0.001), the association with wheeze was independent
of asIgE. There was some evidence that the association between atopy and
wheeze was greater in uninfected subjects compared with those with active geohelminth
infections.
Conclusions and clinical relevance Atopy to house dust mite and cockroach explained few
wheeze cases in our study population, while the presence of anti-Ascaris IgE was an
important risk factor. Our data provided only limited evidence that active geohelminth
infections attenuated the association between atopy and wheeze in endemic areas or that
age modified this association. The role of allergic sensitization to Ascaris in the development
of wheeze, independent of atopy, requires further investigation. | |
dc.language | en | |
dc.publisher | Clinical and Experimental Allergy | |
dc.source | 10.1111/cea.12040 | |
dc.subject | allergen skin test reactivity | |
dc.subject | allergen-specific IgE | |
dc.subject | atopy | |
dc.subject | geohelminths | |
dc.title | Effects of geohelminth infection and age on the associations between allergen-specific IgE, skin test reactivity and wheeze: a case-control study | |
dc.type | Artigo de Periódico | |