dc.contributorCavalcante, Judney Cley
dc.contributorhttp://lattes.cnpq.br/6033996803123759
dc.contributorhttp://lattes.cnpq.br/7975576082142180
dc.contributorCosta, Miriam Stela Maris de Oliveira
dc.contributorhttp://lattes.cnpq.br/8424747565185682
dc.contributorCavalcanti, José Rodolfo Lopes de Paiva
dc.creatorAndrade, Wylqui Mikael Gomes de
dc.date.accessioned2017-11-21T00:04:51Z
dc.date.accessioned2022-10-06T13:50:00Z
dc.date.available2017-11-21T00:04:51Z
dc.date.available2022-10-06T13:50:00Z
dc.date.created2017-11-21T00:04:51Z
dc.date.issued2017-07-24
dc.identifierANDRADE, Wylqui Mikael Gomes de. Distribuição do óxido nítrico no compartimento subcortical do telencéfalo e hipocampo do Mocó (Kerodon rupestris). 2017. 81f. Dissertação (Mestrado em Biologia Estrutural e Funcional) - Centro de Biociências, Universidade Federal do Rio Grande do Norte, Natal, 2017.
dc.identifierhttps://repositorio.ufrn.br/jspui/handle/123456789/24337
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/3973094
dc.description.abstractNitric oxide (NO) is a gaseous molecule that acts as a neurotransmitter, regulating synaptic events and participating in neural functions such as memory and learning. In the nervous system, NO is catalysed by neuronal nitric oxide synthase (nNOS). As a gaseous molecule, NO can diffuse freely trespassing the cells membrane. Because of this NO can act as a retrograde neurotransmitter and is usually treated as a local moderator. NO and nNOS are highly conserved among species and are present in the nervous system of many vertebrates. We performed immunohistochemical anti-nNOS and histochemical for NADPH-diaphorase in order to investigate the distribution of nitrergic cells in the subcortical compartment of the rock cavy (Kerodon rupestris) telencephalon. The data show a heterogeneous distribution of neurons immunoreactive to nNOS or with NADPH-diaphorase activity throughout the subcortical compartment. Neurons immunoreactive to nNOS were observed in the nucleus accumbens, associating NO with mechanisms of addiction and reward; in the nuclei of the amygdala and in the hippocampus, that are associated with learning and memory; in the bed nucleus of the stria terminalis, associated to defense behaviors, analgesia and cardiovascular functions; and in the basal nuclei, suggesting a putative neuroprotector role and neural regulation of the movement, being still associated with neurodegenerative diseases in these regions. The distribution of NO in the subcortical telencephalon of the rock cavy is broad, heterogeneous and complex, suggesting a broad role of NO in the cerebral functions of this species. In addition, the mapping of nNOS distribution is being important for the morphological definition of the rock cavy's brain areas in comparison with other species of rodents and other mammals.
dc.publisherBrasil
dc.publisherUFRN
dc.publisherPROGRAMA DE PÓS-GRADUAÇÃO EM BIOLOGIA ESTRUTURAL E FUNCIONAL
dc.rightsAcesso Aberto
dc.subjectÓxido nítrico
dc.subjectÓxido nítrico sintase
dc.subjectTelencéfalo
dc.subjectKerodon rupestris
dc.titleDistribuição do óxido nítrico no compartimento subcortical do telencéfalo e hipocampo do Mocó (Kerodon rupestris)
dc.typemasterThesis


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