Brasil | masterThesis
dc.contributorSilva, Regina Helena da
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dc.contributorhttp://lattes.cnpq.br/1904811505225591
dc.contributor
dc.contributorhttp://lattes.cnpq.br/0101190051087933
dc.contributorSilva, Flávia Teixeira
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dc.contributorhttp://lattes.cnpq.br/9729753166045101
dc.contributorRachetti, Vanessa de Paula Soares
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dc.contributorhttp://lattes.cnpq.br/1524215726056886
dc.creatorSousa, Diego Silveira
dc.date.accessioned2011-12-29
dc.date.accessioned2014-12-17T15:37:03Z
dc.date.accessioned2022-10-06T13:44:31Z
dc.date.available2011-12-29
dc.date.available2014-12-17T15:37:03Z
dc.date.available2022-10-06T13:44:31Z
dc.date.created2011-12-29
dc.date.created2014-12-17T15:37:03Z
dc.date.issued2011-05-17
dc.identifierSOUSA, Diego Silveira. Influência do ciclo estral no efeito do diazepam na ansiedade e memória de ratas. 2011. 108 f. Dissertação (Mestrado em Estudos de Comportamento; Psicologia Fisiológica) - Universidade Federal do Rio Grande do Norte, Natal, 2011.
dc.identifierhttps://repositorio.ufrn.br/jspui/handle/123456789/17315
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/3972496
dc.description.abstractMemory and anxiety are related phenomena. Several evidences suggest that anxiety is fundamental for learnining and may facilitate or impair the memory formation process depending of the context. The majority of animal studies of anxiety and fear use only males as experimental subjects, while studies with females are rare in the literature. However, the prevalence in phobic and anxiety disorders is greater in women than in men. Moreover, it is known that gender maybe influence benzodiazepine effects, the classic drugs used for anxiety disorders treatment. In this respect, to further investigate if fear/anxiety aspects related to learning in female subjects would contribute to the study of phobic and anxiety disorders and their relationship with learning/memory processes, the present work investigates (a) the effects of benzodiazepine diazepam on female rats performance in a aversive memory task that assess concomitantly anxiety/emotionality, as the interaction between both; (b) the influence of estrous cycle phases of female rats on diazepam effects at aversive memory and anxiety/emotionality, and the interaction between both and (c) the role of hormonal fluctuations during estrous cycle phases in absence of diazepam effects in proestrus, because female rats in this phase received or not mifepristone, the antagonist of progesterone receptor, previously to the diazepam treatment. For this purpose, the plus maze discriminative avoidance task, previously validated for studies of anxiety concomitantly to learning/memory, was used. The apparatus employed is an adaptation of a conventional plus maze, with two opens arms and two closed arms, one of which presenting aversive stimulation (noise and light). The parameters used were: time in non-aversive arm compared to time in aversive and percentage of time in aversive arm on several temporal divisions, in order to evaluate memory; percentage of time in open arms, risk assessment, head dipping and end exploring to evaluate anxiety ; and distance traveled for locomotion. In experiment I, we found anxiolytic effect of diazepam only for 4 mg/kg dose, however the amnestic effect appear at a dose of 2 mg/kg. In second experiment, rats were divided in groups according estrous cycle phase (metaestrus/diestrus, proestrus e estrus). In this experiment, when we considered estrous cycle phase or diazepam treatment, the results did not demonstrate any differences in anxiety/emotionality parameters. The amnestic effects of diazepam occur in female rats in metestrus/diestrus and estrus and is absent in proestrous rats. Proestrous female rats that received mifepristone exhibited the amnestic effect of diazepam and also anxiolytic effects, that it was not previously observed in this dose. The results have demonstrated dissociation of anxiolytic and amnestic diazepam effects, not previously observed in males; the absence of amnestic effect of diazepam in proestrous phase; and the possible role of progesterone in aversive memory over diazepam effect, because the mifepristone, associated with diazepam, caused amnestic effect in proestrus
dc.publisherUniversidade Federal do Rio Grande do Norte
dc.publisherBR
dc.publisherUFRN
dc.publisherPrograma de Pós-Graduação em Psicobiologia
dc.publisherEstudos de Comportamento; Psicologia Fisiológica
dc.rightsAcesso Aberto
dc.subjectMedo
dc.subjectAnsiedade
dc.subjectDiferença de gênero
dc.subjectTranstornos fóbico-ansiosos
dc.subjectEsquiva discriminativa em labirinto em cruz elevado
dc.subjectCiclo estral
dc.subjectDiazepam
dc.subjectMifepristona
dc.subjectFear
dc.subjectAnxiety
dc.subjectGender differences
dc.subjectPhobic and anxiety disorders
dc.subjectPlus maze discriminative avoidance task
dc.subjectEstrous cycle
dc.subjectDiazepam
dc.subjectMifepristone
dc.titleInfluência do ciclo estral no efeito do diazepam na ansiedade e memória de ratas
dc.typemasterThesis


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