doctoralThesis
Perfis imunofenotípicos das doenças linfoproliferativas crônicas no Rio Grande do Norte
Fecha
2018-05-18Registro en:
PAIVA, Aldair de Sousa. Perfis imunofenotípicos das doenças linfoproliferativas crônicas no Rio Grande do Norte. 2018. 156f. Tese (Doutorado em Ciências da Saúde) - Centro de Ciências da Saúde, Universidade Federal do Rio Grande do Norte, Natal, 2018.
Autor
Paiva, Aldair de Sousa
Resumen
Introduction: Chronic Lymphoproliferative Diseases (DLPC) are a group of lymphatic
neoplasms characterized by the proliferation of mature neoplastic lymphocytes.
Immunophenotyping by Flow Cytometry (ICF) is a routine practice in the differential
diagnosis of these tumors, contributing to greater precision. Objectives: To
demonstrate the immunophenotypic profiles of patients with DLPC in Rio Grande do
Norte (RN); Demonstrate the applicability of a specific panel for the diagnosis of
patients with multiple myeloma; Determine the monoclonality of DLPC-B; Implement
database for clinical research Methods: Patients (n = 500) with DLPC were
investigated by CF. In addition, other patient information, such as age, sex and
haematological data, was collected. Results: The results showed that 86.6% of the
cases were DLPC-B and 13.4%, DLPC-T / NK. The distribution of DLPC-B was: 279
Chronic Lymphocytic Leukemia; Prolinfocytic Leukemia B; 11 Vilous Cell Leukemia; 3
Follicular lymphoma; 3 Splenic Lymphoma with Vilous Lymphocytes; 12 Mantle Cell
Lymphoma; 01 Macroglobulinemia of Waldenstron; 47 Multiple Myeloma; 12 Plasma
Cell Leukemia; 09 Burkitt's Lymphoma and 39 NHL-Leucemy. The DLPC classification
of T / NK was: 11 Granular Lymphocyte Leukemia; 14 Prolinfocytic Leukemia T; 10
Adult T-Cell Leukemia; 8 Conclusions: The data demonstrate that
immunophenotyping is a reliable and safe technique in the diagnostic clarification of
patients with DLPC. It was possible to detect monoclonality in DLPC-B. Thediagnosis
of multiple myeloma benefits from the specific panel application. This study
consolidates as a clinical research base for DLPC in Rio Grande do Norte. Approved
by ethics committee in research Hospital Onofre Lopes- UFRN