The fabrics with copper or copper oxide deposition are of considerable interest because of exceptional antibacterial properties, which are useable in medical, textiles, and hygiene applications. Unfortunately, the conventional techniques take long pro-cessing time, complex equipment, and combination of several processing steps (nano-particles synthesis and their deposition on fabrics). In this novel study, cathodic cage plasma deposition assisted with copper cathodic cage is used for the synthesis of the copper oxide on polyester and polyamide fabrics. For the enhancement of synthesis efficiency, the effect of cathodic cage lid thickness is also investigated. The samples are assessed by using scanning electron microscopy, elemental dispersive spectros-copy, and X‐ray photoelectron spectroscopy. It is found that using cathodic cage plasma deposition, fabrics can be successfully synthesized by the copper oxide with comparatively small treatment time, cost‐effectively, and environmentally friendly. Interestingly, cathodic cage plasma treatment is already proved to be working effec- tively on industrial scale; thus, it is predicted to be of noteworthy importance for fab- rics processing on large‐scale garments manufacturing and hospitals.