Alterações bioquímicas em ratos com doença periodontal e tratados com olmesartana, captopril e atorvastatna

Abstract

Introduton: Periodontal disease is an inflannatory processo thet occurs in response to the dental bacterial antgens. As periodontl disese affects adults, especially the elderly, the presence of this pathology in patents with risk factors for cardiovascular disease, while are marking use of drugs becomes a usual fnding. Objectve: To verify the biochemical changes resultng from the use of olmesartan, Captopril or Atovastatna in animals with periodontal disease. Methodology: 50 Wistar rats weighing between 250-400g. Periodontal disease was induced by ligaton of 3-0 nylon thread, for 10 days, the animals received a single oral dose and daily olmesartan (1 and 10mg/Kg), Captopril (1.5 and 10mg/Kg) and Atovastatna (1.5 and 10mg/Kg). On the 11th day each group was euthanized with sodium thiopental at the dose of 20 mg/ kg and blood collected for biochemical evaluaton. The variables studied were glucose, creatnine, urea, total cholesterol, triglycerides, HDL, LDL, AST and ALT reading was performed on equipment BioPlus 2000 ®. To check the differences between groups was used Student's t test with signifcance level of 5% in Graf Pad Install program. Results: Periodontal disease signifcantly elevated glucose levels, LDL-C and total cholesterol (p <0.05). Also in animals treated with atovastatn, an expected pharmacological effect, which was a reducton in LDL-C and increasing HDL-C, were not found. Conclusion: The study showed an important effect of periodontal disease, in response to systemic medicatons.