article
Effects of Purified Saccharomyces cerevisiae (1→3)-β-Glucan on Venous Ulcer Healing
Fecha
2012Registro en:
1422-0067
Autor
Medeiros, Sarah Dantas Viana
Cordeiro, Sara Lima
Cavalcanti, Jéssica Escorel Chaves
Melchuna, Karina Mendes
Lima, Aleida Maria da Silva
Araújo Filho, Irami
Medeiros, Aldo Cunha
Rocha, Keyla Borges Ferreira
Oliveira, Elizabeth Maia
Faria, Eduardo Dantas Baptista
Sassaki, Guilherme Lanzi
Rocha, Hugo Alexandre Oliveira
Sales, Valéria Soraya Farias
Resumen
Water-insoluble glucan was isolated from the baker’s yeast Saccharomyces
cerevisiae. The yeast cells were treated with alkali and the residue then with acid.
Chemical and NMR (1D and 2D) analyses showed that a linear (1→3)-β-glucan was
purified that was not contaminated with other carbohydrates, proteins or phenolic
compounds. The effects of the glucan on wound healing were assessed in human venous
ulcers by histopathological analysis after 30 days of topical treatment. (1→3)-β-glucan
enhanced ulcer healing and increased epithelial hyperplasia, as well as increased
inflammatory cells, angiogenesis and fibroblast proliferation. In one patient who had an
ulcer that would not heal for over 15 years, glucan treatment caused a 67.8% decrease in
the area of the ulcer. This is the first study to investigate the effects of (1→3)-β-glucan on
venous ulcer healing in humans; our findings suggest that this glucan is a potential natural
biological response modifier in wound healing