doctoralThesis
Evidência científica sobre avaliação da musculatura respiratória e tratamento dos distúrbios respiratórios do sono em acidente vascular cerebral
Fecha
2021-08-27Registro en:
YÁÑEZ, Matías Felipe Otto. Evidência científica sobre avaliação da musculatura respiratória e tratamento dos distúrbios respiratórios do sono em acidente vascular cerebral. 2021. 67f. Tese (Doutorado em Biotecnologia) - Centro de Tecnologia, Universidade Federal do Rio Grande do Norte, Natal, 2021.
Autor
Yáñez, Matías Felipe Otto
Resumen
Over the past fourty years, some tests were developed to assess the resistance of
respiratory muscles, especially inspiratory muscles. Devices and prototypes always
sought to assess two relatively distinct aspects: fatigue and endurance. Despite its
importance, previous studies using different devices or prototypes to assess respiratory
muscle resistance used a small sample size, hindering interpretation of results.
Additionally, the nonspecific respiratory endurance test most used, maximum voluntary
ventilation (MVV), was indirectly applied in different populations (e.g., Chronic
Obstructive Pulmonary Disease – [COPD]) for several years using predictive equations.
However, literature lacks studies assessing the concordance of predictive equations
with MVV. Significant progress has also been made in understanding sleep-disordered
breathing and its consequences. Although there is evidence that positive airway
pressure facilitates respiratory muscle activity and improves ventilation and disease
control, its effectiveness is unknown in special populations, such as in post-stroke
patients. This thesis aimed to examine methods for assessing and treating respiratory
disorders in people with chronic diseases. We also evaluated the agreement of the
maximum voluntary ventilation measured directly and indirectly (estimated value) in
COPD patients and healthy subjects and showed the effectiveness and safety of using
continuous positive nasal pressure in functionality, clinical severity of the disease,
disability, daytime sleepiness, and mortality of people after stroke. The designed device
has potential for innovation and can evaluate resistance of respiratory muscles
(inspiratory/expiratory alone or combined) using different protocols. The systematic
review is ongoing. Despite the high heterogeneity of studies, preliminary results support
positive effects of nCPAP on disease severity for more than three months in patients
with stroke and sleep-disordered breathing. These study aimed to evaluate, develop
and examine methods of respiratory muscle assessment and treatment of respiratory
disorders in healthy people or those with COPD and sleep-disordered breathing in
people after stroke.