masterThesis
Efeito antiinflamatório de fucana extraída da alga Parda spatoglossum schroederii em modelos experimentais de Peritonite, choque não séptico e colite
Fecha
2012-05-17Registro en:
SILVA, Ana Katarina Andrade. Efeito antiinflamatório de fucana extraída da alga Parda spatoglossum schroederii em modelos experimentais de
Peritonite, choque não séptico e colite. 2012. 88 f. Dissertação (Mestrado em Biodiversidade; Biologia Estrutural e Funcional.) - Universidade Federal do Rio Grande do Norte, Natal, 2012.
Autor
Silva, Ana Katarina Andrade
Resumen
Fucans is a name used for sulfated polysaccharides, which is most
characteristic structure of the presence of sulfated L-fucose, are found in brown
seaweed (Phaeophyceae) and echinoderms (sea urchins and sea cucumbers).
These polysaccharides have been reported to possess anticoagulant, antitumor,
anti-viral, anti-proliferative and anti-inflammatory activities. Therefore, in
the present study was evaluate the effect of the fucan from the brown seaweed
Spatoglossum schroederii in models of peritonitis and non-septic shock induced
by zymosan, as well as in a murine model of colitis induces by DSS. So, the
mice treatment by intravenous route with the fucan was able to reduce the
exudate formation and the cell migration in the model of acute peritonitis
induced by zymosan during the kinetic of 6, 24 and 48 hours. Similarly, in the
model of non-septic shock induced by zymosan the fucan demonstrated a
protector effect to inhibited the cellular migration to the peritoneo, to decrease
the levels of IL-6 in the serum and in the peritoneal exudate, to attenuate the
lose of weight in the mice; beside to reduce the serum levels of hepatic
transaminases and as well as the liver injury. In the model of murine colitis, the
treatment with the fucan reduced the lose of weight of the animals, decreased
the levels of IL-17 and IFN- produced in the gut and decrease the intestinal
lesion induced by DSS. In conclusion, the fucan used in this study presented a
significant protector effect in the murine models of inflammation