The use of zeolites as support for immobilization of enzymes has been a matter of great interest recently due to the potential properties of these materials. In this work, the MCM 22 zeolite with different Si/Al ratios (15, 25 and 50) was used as support for immobilization of porcine pancreatic lipase, assessing the effect of its structure on the immobilization yield and enzyme activity. Results showed that the material composition influenced significantly the immobilization process. Higher yields of immobilization and enzymatic activities were achieved when MCM 22 with Si/Al ratio of 25 was used as support. In general, results demonstrate the potential of MCM 22 as support for porcine pancreatic lipase immobilization.