dc.contributor | | |
dc.contributor | http://lattes.cnpq.br/1027270422002393 | |
dc.contributor | | |
dc.contributor | http://lattes.cnpq.br/0321740024191482 | |
dc.contributor | Langassner, Silvana Maria Zucolotto | |
dc.contributor | | |
dc.contributor | http://lattes.cnpq.br/7390416147619446 | |
dc.contributor | Klein, Sibele de Oliveira Tozetto | |
dc.contributor | | |
dc.contributor | http://lattes.cnpq.br/6285491619832020 | |
dc.creator | Macedo, José Benilson Martins | |
dc.date.accessioned | 2014-12-03 | |
dc.date.accessioned | 2014-12-17T14:16:37Z | |
dc.date.accessioned | 2022-10-06T12:41:19Z | |
dc.date.available | 2014-12-03 | |
dc.date.available | 2014-12-17T14:16:37Z | |
dc.date.available | 2022-10-06T12:41:19Z | |
dc.date.created | 2014-12-03 | |
dc.date.created | 2014-12-17T14:16:37Z | |
dc.date.issued | 2011-05-31 | |
dc.identifier | MACEDO, José Benilson Martins. Capacidade antioxidante in vitro e avaliação da toxicidade aguda in vivo de extratos de folhas de Licania rígida Benth., Licania tomentosa (Benth.) Fritsch e Couepia impressa Prance (Chrysobalanaceae). 2011. 105 f. Dissertação (Mestrado em Bioanálises e Medicamentos) - Universidade Federal do Rio Grande do Norte, Natal, 2011. | |
dc.identifier | https://repositorio.ufrn.br/jspui/handle/123456789/13510 | |
dc.identifier.uri | http://repositorioslatinoamericanos.uchile.cl/handle/2250/3957167 | |
dc.description.abstract | Licania rigida Benth., Licania tomentosa (Benth.) Fritsch, and Couepia impressa
Prance (Chrysobalanaceae family) plants have long been used medicinally by
the people from Northeastern Brazil. Crude extracts and infusions of these
plants have been applied in the treatment of several conditions such as
diabetes and rheumatism, degenerative diseases with involvement of reactive
oxygen species (ROS). The aim of this study was to evaluate the aqueous,
ethanolic, and hydroethanolic leaves extracts antioxidant capacity of these
species, using several in vitro assay systems (reducing power, DPPH●
scavenging, the β-carotene linoleate model system and lipid peroxidation
inhibition in rat brain homogenate, using thiobarbituric acid reactive substances
- TBARS). The oral acute toxicity of aqueous extracts was also evaluated in
vivo. Results revealed that these extracts possess a potent reducing power and
DPPH scavenging ability, as well as the ability to prevent TBARS formation in
rat brain homogenate in a concentration-dependent manner. Regarding in vivo
oral acute toxicity of the aqueous species extracts, no toxic effects were
observed upon evaluating physiological, hematological and biochemical
parameters. The presence of high levels of phenolics and flavonoids was
determined mainly in the ethanol extract. However, the C. impressa
hydroethanolic extract, fractionated with hexane, chloroform and ethyl acetate
for analysis by NMR 1H, showed more efficient results than the reference
antioxidant Carduus marianus. The classes of organics compounds were
determined were phenolics in the fraction of ethyl acetate and terpenes in
chloroform and hexane fractions. The ethil acetate fraction had the highest
content of flavonoids and increased scavenging capacity of DPPH●, possibly by
the presence of phenolic compounds. Therefore, a detailed investigation of the
phytochemical composition and in vivo study of the C. impressa hydroethanolic
extract is suggested to characterize the active compounds of the species | |
dc.publisher | Universidade Federal do Rio Grande do Norte | |
dc.publisher | BR | |
dc.publisher | UFRN | |
dc.publisher | Programa de Pós-Graduação em Ciências Farmacêuticas | |
dc.publisher | Bioanálises e Medicamentos | |
dc.rights | Acesso Aberto | |
dc.subject | Licania rigida. Licania tomentosa. Couepia impressa.
Compostos fenólicos. Flavonoides. Capacidade antioxidante | |
dc.subject | Licania rigida. Licania tomentosa. Couepia impressa. Phenolic
compounds. Flavonoids. Antioxidant capacity | |
dc.title | Capacidade antioxidante in vitro e avaliação da toxicidade aguda in vivo de extratos de folhas de Licania rígida Benth., Licania tomentosa (Benth.) Fritsch e Couepia impressa Prance (Chrysobalanaceae) | |
dc.type | masterThesis | |