Cintura hipertrigliceridêmica e alterações cardiometabólicas em adolescentes com sobrepeso/obesidade

Abstract

Excess body weight, especially in the abdominal region, is associated with a set of cardiometabolic alterations, such as dyslipidemia, arterial hypertension, insulin resistance, hyperinsulinemia. In this sense, the hypertriglyceridemic waist phenotype, characterized by the simultaneous association of elevated triglyceride concentrations with increased waist circumference, has been a proposed parameter capable of predicting an atherogenic metabolic triad status in both adults and adolescents. Objective: To identify the frequency of the hypertriglyceridemic waist phenotype and to evaluate its association with cardiometabolic risks in overweight / obese adolescents. Methods. A cross-sectional study involving overweight / obese adolescents aged 10 to 19 attended at the pediatric endocrinology outpatient clinic of the Onofre Lopes University Hospital, Natal, RN. The participants were submitted to anthropometric evaluation (weight, height and waist circumference) and blood collection to the levels of total cholesterol, LDL-c, HDL-c, triglycerides, fasting glycemia and HOMA-IR. The CH phenotype was defined by the simultaneous presence of increased waist circumference (≥ 90th percentile by age and sex) and elevated serum triglyceride levels (≥ 100 mg / dL).Results: The HW phenotype was more present in adolescents classified as obese or severely obese. The results of the bivariate analysis showed that the variables Total Cholesterol (OR = 5 CI 95% 1.1-27.2), LDL-C (OR = 9.1 CI 95% 1.9-52.9), Insulin Fasting (OR = 9.7 IC95% 1.7-73.2) and Homa Index (OR = 7.3 95% CI 1.2-55.7) were associated with the presence of the HW phenotype. The results of the multivariate analysis, adjusted for all variables analyzed, showed that only LDL-c (OR = 19.7 CI 95% 2.9-132) and anthropometric nutritional status (OR = 9.9 CI 95% 1.8 -54.1) presented a positive association with the presence of the HW phenotype. Conclusions: The phenotype was associated with an atherogenic lipid profile, being a predictor of cardiometabolic risk.