The present study aims to present a system for the production of nano particles of poly (methyl methacrylate) (PMMA) and polycaprolactone (PCL) based on the atomization of polymer solution in anti-solvent medium. In this system, polymer solutions are prepared and atomized in the form of a spray. The droplets generated from atomization come into contact with anti-solvent liquid that causes the precipitation and formation of the polymeric nanoparticles. In this study, experiments using the proposed system were performed under different operating conditions and the particles obtained were analyzed by dynamic light scattering (DLS) and transmission electron microscopy (TEM). The results demonstrated nano and microparticles with a size distribution ranging from 50 to 3000 nm. The morphology and the particle size distribution (PSD) was modified by simple changes in the synthesis as the nature of the polymer, the type of solvent, the atomization pressure and the temperature of the anti-solvent liquid