AMPA receptors mediate passive avoidance deficits induced by sleep deprivation

dc.creatorDubiela, Francisco Paulino
dc.creatorQueiroz, Claudio Marcos Teixeira de
dc.creatorMoreira, Karin Di Monteiro
dc.creatorNobrega, Jose N.
dc.creatorSita, Luciane Valéria
dc.creatorTufik, Sergio
dc.creatorHipolide, Debora Cristina
dc.date2017-05-31T17:01:35Z
dc.date2017-05-31T17:01:35Z
dc.date2013
dc.identifierhttps://repositorio.ufrn.br/jspui/handle/123456789/23289
dc.identifier10.1016/j.bbr.2013.09.037
dc.descriptionThe present study addressed the effects of sleep deprivation (SD) on AMPA receptor (AMPAR) binding in brain regions associated with learning and memory, and investigated whether treatment with drugs acting on AMPAR could prevent passive avoidance deficits in sleep deprived animals. [(3)H]AMPA binding and GluR1 in situ hybridization signals were quantified in different brain regions of male Wistar rats either immediately after 96 h of sleep deprivation or after 24h of sleep recovery following 96 h of sleep deprivation. Another group of animals were sleep deprived and then treated with either the AMPAR potentiator, aniracetam (25, 50 and 100mg/kg, acute administration) or the AMPAR antagonist GYKI-52466 (5 and 10mg/kg, acute and chronic administration) before passive avoidance training. Task performance was evaluated 2h and 24h after training. A significant reduction in [(3)H]AMPA binding was found in the hippocampal formation of SD animals, while no alterations were observed in GluR1 mRNA levels. The highest dose of aniracetam (100mg/kg) reverted SD-induced impairment of passive avoidance performance in both retention tests, whereas GYKI-52466 treatment had no effect. Pharmacological enhancement of AMPAR function may revert hippocampal-dependent learning impairments produced after SD. We argue that such effects might be associated with reduced AMPAR binding in the hippocampus of sleep deprived animals.
dc.languageeng
dc.rightsAcesso Aberto
dc.subjectAMPA receptor
dc.subjectAniracetam
dc.subjectGYKI-52466
dc.subjectPassive avoidance task
dc.subjectSleep deprivation
dc.titleAMPA receptors mediate passive avoidance deficits induced by sleep deprivation
dc.typearticle


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