masterThesis
Parâmetros funcionais de crianças saudáveis suplementadas com zinco e de meninos com distrofia muscular de Duchenne
Fecha
2019-05-23Registro en:
VERMEULEN, Karina Marques. Parâmetros funcionais de crianças saudáveis suplementadas com zinco e de meninos com distrofia muscular de Duchenne. 2019. 66f. Dissertação (Mestrado em Ciências da Saúde) - Centro de Ciências da Saúde, Universidade Federal do Rio Grande do Norte, Natal, 2019.
Autor
Vermeulen, Karina Marques
Resumen
Childhood is a period of rapid growth and development. Zinc is a micronutrient that
exerts essential structural functions and acts in the maintenance of cellular function.
Functional indicators of nutritional status for the evaluation of children include
anthropometric indices and measures of body composition assessment. The
parameters derived from bioelectrical impedance, phase angle (AP) and bioelectrical
impedance vector analysis (BIVA) have been associated with the integrity of the cell
membrane and cellular body mass. Also, BIVA is useful in evaluating other clinical
conditions, where traditional assessment methods are not reliable. Duchenne
muscular dystrophy (DMD) is a disease characterized by progressive loss of functional
muscle mass followed by changes in body composition. To date, no studies are
evaluating the influence of different doses of oral zinc supplementation on cell integrity
and functionality, using AF and BIVA as evaluation methods. This dissertation aimed
to analyze the functional parameters in healthy children supplemented with zinc and
described the functional parameters in children with DMD. For this to happen, two
studies were conducted. The first one evaluated changes in the functional parameters
of 71 healthy children supplemented orally with zinc at different concentrations (Study
1) and the second described the functional parameters in 41 boys with DMD (Study 2).
As a result, we have seen that for healthy children supplementation with 10 mg-Zn /
day promoted changes in cell membrane integrity associated with increased cell mass.
We also found that, in comparison with the reference population, boys with DMD had
lower levels of body cell mass. Understanding that zinc plays a vital role in the cell
membrane, the results of this dissertation will serve as the basis for a future study
evaluating oral zinc supplementation in other populations, such as boys with DMD.