dc.contributor | | |
dc.contributor | http://lattes.cnpq.br/0893922249078027 | |
dc.contributor | | |
dc.contributor | http://lattes.cnpq.br/2929963416385218 | |
dc.contributor | Tambourgi, Denise Vilarinho | |
dc.contributor | | |
dc.contributor | http://lattes.cnpq.br/9562680870970641 | |
dc.contributor | Gavioli, Elaine Cristina | |
dc.contributor | | |
dc.contributor | http://lattes.cnpq.br/1759328747578795 | |
dc.contributor | Freitas, Janaina Cristiana de Oliveira Crispim | |
dc.contributor | | |
dc.contributor | http://lattes.cnpq.br/2644540835478572 | |
dc.contributor | Silva, Wilmar Dias da | |
dc.contributor | | |
dc.contributor | http://lattes.cnpq.br/2762547320425528 | |
dc.creator | Bitencourt, Mariana Angélica Oliveira | |
dc.date.accessioned | 2016-03-28T20:16:41Z | |
dc.date.accessioned | 2022-10-05T23:01:04Z | |
dc.date.available | 2016-03-28T20:16:41Z | |
dc.date.available | 2022-10-05T23:01:04Z | |
dc.date.created | 2016-03-28T20:16:41Z | |
dc.date.issued | 2015-03-20 | |
dc.identifier | BITENCOURT, Mariana Angélica Oliveira. Avaliação anti-inflamatória e antipeçonhenta das espécies Hancornia speciosa e Mimosa tenuiflora em modelos experimentais de inflamação e envenenamento induzidos por Bothrops jararaca e Tityus serrulatus. 2015. 164f. Tese (Doutorado em Desenvolvimento e Inovação Tecnológica em Medicamentos) - Centro de Ciências da Saúde, Universidade Federal do Rio Grande do Norte, Natal, 2015. | |
dc.identifier | https://repositorio.ufrn.br/jspui/handle/123456789/20110 | |
dc.identifier.uri | http://repositorioslatinoamericanos.uchile.cl/handle/2250/3944567 | |
dc.description.abstract | Accidents caused by venomous animals represents a significant and serious
public health problem in certain regions of Brazil, as well as in other parts of the world
by the frequency with which they occur and the mortality they cause. The use of plant
extracts as an antidote for poisoning cases is an ancient practice used in many
communities that have no access to antivenom. Medicinal plants represent an important
source of obtaining bioactive compounds able to assist directly in the treatment of
poisoning or indirectly supplementing serum therapy currently used. The aim of this
study was to evaluate the effect of extracts, fractions and isolated compounds from M.
tenuiflora and H. speciosa in the inflammatory process induced by carrageenan and the
venom of B. jararaca and T. serrulatus. The results showed that both M. tenuiflora and
H. speciosa were capable of inhibiting cell migration and cytokines levels in peritonitis
induced by carrageenin and venom of T. serrulatus. In poisoning by B. jararaca model,
mice treated with the plants in studies decreased the leukocyte influx into the peritoneal
cavity. Finally the M. tenuiflora and H. speciosa had antiphlogistic activity, reducing
edema formation and exerted inhibitory action of leukocyte migration in local
inflammation induced by the venom of B. jararaca. Through of Thin Layer
Chromatography (TLC) analysis was possible identified the presence of flavonoids
,saponins and/or terpenes in aqueous extract of M. tenuiflora. By High Performance
Liquid Chromatography analysis, it was possible to identify the presence of rutin and
chlorogenic acid in aqueous extract of H. speciosa. We conclude that the administration
of extracts, fractions and isolated compounds of H. speciosa and M. tenuiflora resulted
in inhibition of the inflammatory process in different experimental models. This study
demonstrates for the first time the effect of M. tenuiflora and H. speciosa in inhibition
of the inflammation caused by B. jararaca and T. serrulatus venom. | |
dc.language | por | |
dc.publisher | Universidade Federal do Rio Grande do Norte | |
dc.publisher | Brasil | |
dc.publisher | UFRN | |
dc.publisher | PROGRAMA DE PÓS-GRADUAÇÃO EM DESENVOLVIMENTO E INOVAÇÃO TECNOLÓGICA EM MEDICAMENTOS | |
dc.rights | Acesso Aberto | |
dc.subject | Mimosa tenuiflora | |
dc.subject | Harconia speciosa | |
dc.subject | Bothrops jararaca | |
dc.subject | Tityus serrulatus | |
dc.subject | Inflamação | |
dc.title | Avaliação anti-inflamatória e antipeçonhenta das espécies Hancornia speciosa e Mimosa tenuiflora em modelos experimentais de inflamação e envenenamento induzidos por Bothrops jararaca e Tityus serrulatus | |
dc.type | doctoralThesis | |