Artigo
Recent mouse and rat methods for the study of experimental oral candidiasis
Fecha
2013-07-17Registro en:
Virulence, v. 4, n. 5, p. 391-399, 2013.
2150-5594
2150-5608
10.4161/viru.25199
WOS:000323324200007
2-s2.0-84880078584
2-s2.0-84880078584.pdf
0322020541055900
Autor
Universidade Estadual Paulista (Unesp)
Hans-Knoell-Institute
Resumen
The Candida genus expresses virulence factors that, when combined with immunosuppression and other risk factors, can cause different manifestations of oral candidiasis. The treatment of mucosal infections caused by Candida and the elucidation of the disease process have proven challenging. Therefore, the study of experimentally induced oral candidiasis in rats and mice is useful to clarify the etiopathology of this condition, improve diagnosis, and search for new therapeutic options because the disease process in these animals is similar to that of human candidiasis lesions. Here, we describe and discuss new studies involving rat and mouse models of oral candidiasis with respect to methods for inducing experimental infection, methods for evaluating the development of experimental candidiasis, and new treatment strategies for oral candidiasis. © 2013 Landes Bioscience.