High-sucrose effect on bone structure, hardness and biomechanics in an obesity model using Wistar male rats

dc.contributorUniversidade Estadual Paulista (Unesp)
dc.creatorCarvalho, Antonio Augusto Ferreira [UNESP]
dc.creatorNakamune, Ana Cláudia de Melo Stevanato [UNESP]
dc.creatorBiffe, B. G. [UNESP]
dc.creatorLouzada, Mário Jefferson Quirino [UNESP]
dc.date2014-05-27T11:26:51Z
dc.date2014-05-27T11:26:51Z
dc.date2012-06-14
dc.identifierhttp://jms.org.br/v29n1/08
dc.identifierJournal of Morphological Sciences, v. 29, n. 1, p. 32-37, 2012.
dc.identifier2177-0298
dc.identifierhttp://hdl.handle.net/11449/73383
dc.identifier2-s2.0-84862028002
dc.identifier2-s2.0-84862028002.pdf
dc.descriptionIntroduction: Excessive consumption of sugar-sweetened beverage is positively related to overweight. Despite the epidemic of childhood obesity, body mass can have a positive or negative effect on bone health. Material and methods: Wistar rats 8 weeks olds were randomly assigned to consume water (Control group, n = 10), sucrose 30% (HS group, n = 10) and water + sucrose 30% (WHS group, n = 14) for 8 weeks. All animals received standard laboratory chow ad libitum. Femur measurements included microhardness, bone mineral density (BMD) by DXA, mechanical compression test and microcomputed tomography (microCT) analysis. Results: We observed significant difference in final body weight in HS and WHS groups, significant increase in triacylglycerol/fructosamine in HS and WHS groups, significantly high BMD in WHS group, increased periosteal/endosteal cortical microhardness in WHS group. Compared with control, microCT parameters evidenced lower amount of connected trabecular bone, decreased bone volume, lower trabecular number with high trabecular separation in distal epiphysis in WHS animals. Conclusion: High-sucrose consumption causes obesity induced by a liquid diet with negative effects on cancellous bone.
dc.descriptionDepartment of Pathology Araçatuba Dental School São Paulo State University - UNESP, CEP 16015050, Araçatuba, SP
dc.descriptionBasic Sciences Department Araçatuba Dental School São Paulo State University - UNESP, CEP 16015050, Araçatuba, SP
dc.descriptionSupport, Production and Animal Health Department Veterinary Medicine School São Paulo State University - UNESP, CEP16050-680, Araçatuba, SP
dc.descriptionDepartment of Pathology Araçatuba Dental School São Paulo State University - UNESP, CEP 16015050, Araçatuba, SP
dc.descriptionBasic Sciences Department Araçatuba Dental School São Paulo State University - UNESP, CEP 16015050, Araçatuba, SP
dc.descriptionSupport, Production and Animal Health Department Veterinary Medicine School São Paulo State University - UNESP, CEP16050-680, Araçatuba, SP
dc.format32-37
dc.languageeng
dc.relationJournal of Morphological Sciences
dc.relation0,115
dc.rightsAcesso aberto
dc.sourceScopus
dc.subjectCortical bone
dc.subjectObesity
dc.subjectRats
dc.subjectSucrose
dc.subjectTrabecular boné
dc.titleHigh-sucrose effect on bone structure, hardness and biomechanics in an obesity model using Wistar male rats
dc.typeArtigo


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