dc.contributor | Universidade de São Paulo (USP) | |
dc.contributor | Hospital Cruzeiro do Sul | |
dc.contributor | Santa Casa de São Paulo | |
dc.contributor | Universidade Estadual Paulista (Unesp) | |
dc.contributor | Instituto da Pele Ltda. | |
dc.contributor | Pontifícia Universidade Católica do Rio Grande do Sul (PUCRS) | |
dc.contributor | Eurofarma Laboratórios Ltda. | |
dc.date.accessioned | 2014-05-27T11:24:42Z | |
dc.date.accessioned | 2022-10-05T18:21:22Z | |
dc.date.available | 2014-05-27T11:24:42Z | |
dc.date.available | 2022-10-05T18:21:22Z | |
dc.date.created | 2014-05-27T11:24:42Z | |
dc.date.issued | 2010-06-01 | |
dc.identifier | Revista Brasileira de Medicina, v. 67, n. 6, p. 195-200, 2010. | |
dc.identifier | 0034-7264 | |
dc.identifier | http://hdl.handle.net/11449/71713 | |
dc.identifier | 2-s2.0-77954961659 | |
dc.identifier.uri | http://repositorioslatinoamericanos.uchile.cl/handle/2250/3920852 | |
dc.description.abstract | Aim: This study aimed to evaluate the efficacy of a new topical drug (EF028) in two separate presentations (aerosol and cream) in a comparative way with the already registered medication, Andolba® (benzocaine, benzoxiquina chloride benzeconio, menthol) and the negative control (hygiene), in the analgesic efficacy after episiotomy wound, reducing the requirement for systemic medication. Methods: 60 patients were voluntary post normal vaginal childbirth with episiotomy, were divided into four groups to comparatively assess the action of the product EF028 (cream and aerosol), Andolba® and soap, the efficacy of decreasing painful symptoms from daily use for 2 times a day for seven days. Clinical assessments and subjective pain occurred daily until the third postoperative day and on the 7th postoperative day. Results: The results showed that the drugs promoted a reduction of painful symptoms and there was no statistically significant difference (p <0.05) between presentations of drug EF028 (cream and aerosol) and Andolba® and the three products were significantly higher (p <0.05) to the control. Conclusions: The evaluated drugs EF028 aerosol, EF028 cream and Andolba® had similar efficacy in relieving the painful symptoms of the perineal region in postoperative episiotomy can be considered as indication for postoperative episiotomies. © Copyright Moreira Jr. Editora. | |
dc.language | por | |
dc.relation | Revista Brasileira de Medicina | |
dc.relation | 0,101 | |
dc.rights | Acesso aberto | |
dc.source | Scopus | |
dc.subject | Episiotomy | |
dc.subject | Local anesthesia | |
dc.subject | Normal childbirth | |
dc.subject | analgesic agent | |
dc.subject | andolba | |
dc.subject | benzocaine | |
dc.subject | benzocaine plus menthol | |
dc.subject | ef 028 | |
dc.subject | menthol | |
dc.subject | unclassified drug | |
dc.subject | adult | |
dc.subject | analgesic activity | |
dc.subject | clinical trial | |
dc.subject | controlled clinical trial | |
dc.subject | controlled study | |
dc.subject | drug dosage form comparison | |
dc.subject | drug efficacy | |
dc.subject | drug screening | |
dc.subject | episiotomy | |
dc.subject | female | |
dc.subject | human | |
dc.subject | major clinical study | |
dc.subject | open study | |
dc.subject | pain assessment | |
dc.subject | postoperative pain | |
dc.subject | randomized controlled trial | |
dc.subject | treatment response | |
dc.subject | vaginal delivery | |
dc.title | Estudo clínico randomizado e aberto para avaliação de eficácia e superioridade dos medicamentos EF028 aerossol, EF028 creme e Andolba® frente ao tratamento controle e comparativo de não inferioridade entre os medicamentos EF028 aerossol, EF028 creme e Andolba® para avaliação de eficácia na redução da sintomatologia dolorosa | |
dc.type | Artigo | |