Research of new mixed-chelate copper complexes with quinoxaline N 1,N 4,-dioxide derivatives and alanine as ligands, potential antimycobacterial agents

dc.contributorCátedra de Química Inorgánica
dc.contributorUniversidade de São Paulo (USP)
dc.contributorUniversidad de Navarra
dc.contributorUniversidade Estadual Paulista (Unesp)
dc.contributorUniversidad de la República, Gral
dc.date.accessioned2014-05-27T11:23:51Z
dc.date.accessioned2022-10-05T18:15:50Z
dc.date.available2014-05-27T11:23:51Z
dc.date.available2022-10-05T18:15:50Z
dc.date.created2014-05-27T11:23:51Z
dc.date.issued2009-01-01
dc.identifierJournal of the Argentine Chemical Society, v. 97, n. 1, p. 80-89, 2009.
dc.identifier0365-0375
dc.identifierhttp://hdl.handle.net/11449/70908
dc.identifier2-s2.0-79959608363
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/3920162
dc.description.abstractThree new mixed-chelate copper complexes with 3-aminoquinoxaline-2-carbonitrile N 1,N 4-dioxide derivatives and alanine as ligands were synthesized in solid state. The spectroscopic characterization (FTIR, EPR, UV-Vis) showed that copper coordinated through the amine and the N-oxide groups of the quinoxaline derivatives and the amine and carboxylate moieties from alanine forming a dimeric species. The tree complexes showed in vitro activity against M. tuberculosis H 37Rv (ATCC 27294) similar to that of ethambutol while they are inactive against E. coli and S. aureus.
dc.languageeng
dc.relationJournal of the Argentine Chemical Society
dc.relation0,123
dc.rightsAcesso restrito
dc.sourceScopus
dc.subjectAntimycobacterial agents
dc.subjectCopper complexes
dc.subjectQuinoxaline derivatives
dc.titleResearch of new mixed-chelate copper complexes with quinoxaline N 1,N 4,-dioxide derivatives and alanine as ligands, potential antimycobacterial agents
dc.typeArtigo


Este ítem pertenece a la siguiente institución