Myeloperoxidase inhibitory and radical scavenging activities of flavones from Pterogyne nitens

dc.contributorUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2014-05-27T11:23:32Z
dc.date.accessioned2022-10-05T18:12:09Z
dc.date.available2014-05-27T11:23:32Z
dc.date.available2022-10-05T18:12:09Z
dc.date.created2014-05-27T11:23:32Z
dc.date.issued2008-05-19
dc.identifierChemical and Pharmaceutical Bulletin, v. 56, n. 5, p. 723-726, 2008.
dc.identifier0009-2363
dc.identifier1347-5223
dc.identifierhttp://hdl.handle.net/11449/70410
dc.identifier10.1248/cpb.56.723
dc.identifierWOS:000256184200021
dc.identifier2-s2.0-43449110138
dc.identifier4484083685251673
dc.identifier4702004904231248
dc.identifier0992736452764550
dc.identifier0000-0002-1516-7765
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/3919712
dc.description.abstractTwo new flavone glucosides, nitensosides A and B (1, 2), together with four known compounds, sorbifolin (3), sorbifolin 6-O-β-glucopyranoside (4), pedalitin (5), and pedalitin 6-O-β-glucopyranoside (6) were isolated from Pterogyne nitens. Their structures were elucidated from 1D and 2D NMR analysis, as well as by high resolution mass spectrometry. All the isolated flavones were evaluated for their myeloperoxidase (MPO) inhibitory activity. The most active compound, pedalitin, exhibited IC 50 value of 3.75 nM on MPO. Additionally, the radical-scavenging capacity of flavones 1-6 was evaluated towards ABTS and DPPH radicals and compared to standard compounds quercetin and Trolox®. © 2008 Pharmaceutical Society of Japan.
dc.languageeng
dc.relationChemical and Pharmaceutical Bulletin
dc.relation1.258
dc.relation0,364
dc.relation0,364
dc.rightsAcesso aberto
dc.sourceScopus
dc.subjectAntioxidant
dc.subjectFlavone
dc.subjectMyeloperoxidase
dc.subjectPterogyne nitens
dc.subjectRadical scavenging
dc.subjectflavone derivative
dc.subjectglucoside
dc.subjectmyeloperoxidase
dc.subjectnitensoside a
dc.subjectnitensoside b
dc.subjectpedalitin
dc.subjectpedalitin 6 o beta glucopyranoside
dc.subjectsorbifolin
dc.subjectsorbifolin 6 o beta glucopyranoside
dc.subjectcontrolled study
dc.subjectdrug inhibition
dc.subjectdrug structure
dc.subjectIC 50
dc.subjectlegume
dc.subjectnonhuman
dc.subjectnuclear magnetic resonance
dc.subjectBenzothiazoles
dc.subjectEnzyme Inhibitors
dc.subjectFabaceae
dc.subjectFlavones
dc.subjectFree Radical Scavengers
dc.subjectGlucosides
dc.subjectMagnetic Resonance Spectroscopy
dc.subjectPeroxidase
dc.subjectPicrates
dc.subjectPlant Leaves
dc.subjectSulfonic Acids
dc.titleMyeloperoxidase inhibitory and radical scavenging activities of flavones from Pterogyne nitens
dc.typeArtigo


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