dc.contributor | Universidade Estadual Paulista (Unesp) | |
dc.contributor | Universidade do Vale do Itajaí-UNIVALI | |
dc.date.accessioned | 2014-05-27T11:22:40Z | |
dc.date.accessioned | 2022-10-05T18:09:39Z | |
dc.date.available | 2014-05-27T11:22:40Z | |
dc.date.available | 2022-10-05T18:09:39Z | |
dc.date.created | 2014-05-27T11:22:40Z | |
dc.date.issued | 2007-12-01 | |
dc.identifier | Cytologia, v. 72, n. 4, p. 401-407, 2007. | |
dc.identifier | 0011-4545 | |
dc.identifier | http://hdl.handle.net/11449/70044 | |
dc.identifier | 10.1508/cytologia.72.401 | |
dc.identifier | 2-s2.0-39349107050 | |
dc.identifier | 2-s2.0-39349107050.pdf | |
dc.identifier | 4787521613038315 | |
dc.identifier | 0000-0003-0757-7876 | |
dc.identifier.uri | http://repositorioslatinoamericanos.uchile.cl/handle/2250/3919401 | |
dc.description.abstract | Casearia sylvestris (Flacourtiaceae) is a plant which grows in wild and has been widely used in folk medicine. In this study, clastogenic/aneugenic properties of Casearia sylvestris crude ethanolic extract were evaluated using in vivo chromosomal aberrations (CAs) and micronucleus (MN) assays in rodents. The animals were treated by gavage with 3 concentrations of the extract: 150, 300 and 500 mg/kg body weight. Bone marrow cells from Wistar rats were collected 24 h after having been submitted to the MN and CAs test. Peripheral blood cells from Swiss mice were collected 48 and 72 h after having been submitted to the MN test. The results show that C. sylvestris extract does not induce a significant increase in mean values for micronucleated polychromatic erythrocytes (MNPCE) in Swiss mice and Wistar rats, or CAs in rat bone marrow cells, at the 3 tested doses, indicating that the extract showed no clastogenic/aneugenic effects on chromosomes of the rodent cells tested. © 2007 The Japan Mendel Society. | |
dc.language | eng | |
dc.relation | Cytologia | |
dc.relation | 0.481 | |
dc.relation | 0,233 | |
dc.rights | Acesso aberto | |
dc.source | Scopus | |
dc.subject | Casearia sylvestris | |
dc.subject | Chromosome aberration | |
dc.subject | In vivo | |
dc.subject | Micronucleus test | |
dc.subject | Animalia | |
dc.subject | Casearia | |
dc.subject | Flacourtiaceae | |
dc.subject | Mus | |
dc.subject | Rattus | |
dc.subject | Rattus norvegicus | |
dc.subject | Rodentia | |
dc.title | Assessment of the potential clastogenic/aneugenic risk of Casearia sylvestris extract using in vivo assays | |
dc.type | Artigo | |