dc.contributorUniversidade Estadual Paulista (Unesp)
dc.contributorUniversidade do Vale do Itajaí-UNIVALI
dc.date.accessioned2014-05-27T11:22:40Z
dc.date.accessioned2022-10-05T18:09:39Z
dc.date.available2014-05-27T11:22:40Z
dc.date.available2022-10-05T18:09:39Z
dc.date.created2014-05-27T11:22:40Z
dc.date.issued2007-12-01
dc.identifierCytologia, v. 72, n. 4, p. 401-407, 2007.
dc.identifier0011-4545
dc.identifierhttp://hdl.handle.net/11449/70044
dc.identifier10.1508/cytologia.72.401
dc.identifier2-s2.0-39349107050
dc.identifier2-s2.0-39349107050.pdf
dc.identifier4787521613038315
dc.identifier0000-0003-0757-7876
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/3919401
dc.description.abstractCasearia sylvestris (Flacourtiaceae) is a plant which grows in wild and has been widely used in folk medicine. In this study, clastogenic/aneugenic properties of Casearia sylvestris crude ethanolic extract were evaluated using in vivo chromosomal aberrations (CAs) and micronucleus (MN) assays in rodents. The animals were treated by gavage with 3 concentrations of the extract: 150, 300 and 500 mg/kg body weight. Bone marrow cells from Wistar rats were collected 24 h after having been submitted to the MN and CAs test. Peripheral blood cells from Swiss mice were collected 48 and 72 h after having been submitted to the MN test. The results show that C. sylvestris extract does not induce a significant increase in mean values for micronucleated polychromatic erythrocytes (MNPCE) in Swiss mice and Wistar rats, or CAs in rat bone marrow cells, at the 3 tested doses, indicating that the extract showed no clastogenic/aneugenic effects on chromosomes of the rodent cells tested. © 2007 The Japan Mendel Society.
dc.languageeng
dc.relationCytologia
dc.relation0.481
dc.relation0,233
dc.rightsAcesso aberto
dc.sourceScopus
dc.subjectCasearia sylvestris
dc.subjectChromosome aberration
dc.subjectIn vivo
dc.subjectMicronucleus test
dc.subjectAnimalia
dc.subjectCasearia
dc.subjectFlacourtiaceae
dc.subjectMus
dc.subjectRattus
dc.subjectRattus norvegicus
dc.subjectRodentia
dc.titleAssessment of the potential clastogenic/aneugenic risk of Casearia sylvestris extract using in vivo assays
dc.typeArtigo


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