dc.contributorInstitute of Biomedical Sciences
dc.contributorUniversidade Estadual Paulista (Unesp)
dc.contributorFederal University of Rio Grande do Norte
dc.contributorUniversidade de São Paulo (USP)
dc.date.accessioned2014-05-27T11:22:28Z
dc.date.accessioned2022-10-05T18:07:02Z
dc.date.available2014-05-27T11:22:28Z
dc.date.available2022-10-05T18:07:02Z
dc.date.created2014-05-27T11:22:28Z
dc.date.issued2007-05-14
dc.identifierBrain Research, v. 1149, n. 1, p. 101-110, 2007.
dc.identifier0006-8993
dc.identifierhttp://hdl.handle.net/11449/69664
dc.identifier10.1016/j.brainres.2007.02.048
dc.identifier2-s2.0-34247504164
dc.identifier8372363591179624
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/3919075
dc.description.abstractThe suprachiasmatic nucleus, an essential diencephalic component of the circadian timing system, plays a role in the generation and modulation of behavioral and neuroendocrine rhythms in mammals. Its cytoarchitecture, neurochemical and hodological characteristics have been investigated in various mammalian species, particularly in rodents. In most species, two subdivisions, based on these aspects and considered to reflect functional specialization within the nucleus, can be recognized. Many studies reveal a typical dense innervation by serotonergic fibers in this nucleus, mainly in the ventromedial area, overlapping the retinal afferents. However, a different pattern occurs in certain animals, which lead us to investigate the distribution of serotonergic afferents in the suprachiasmatic nucleus of the Capuchin monkey, Cebus apella, compared to the marmoset, Callithrix jacchus, and two Rattus norvegicus lines (Long Evans and Wistar), and to reported findings for other mammalian species. Our morphometric data show the volume and length of the suprachiasmatic nucleus along the rostrocaudal axis to be greatest in C. apella > C. jacchus > Long Evans ≥ Wistar rats, in agreement with their body sizes. In C. apella, however, the serotonergic terminals occupy only some 10% of the nucleus' area, less than the 25% seen in the marmoset and rats. The distribution of the serotonergic fibers in C. apella does not follow the characteristic ventral organization pattern seen in the rodents. These findings raise questions concerning the intrinsic organization of the nucleus, as well as regarding the functional relationship between serotonergic input and retinal afferents in this diurnal species. © 2007 Elsevier B.V. All rights reserved.
dc.languageeng
dc.relationBrain Research
dc.relation3.125
dc.relation1,404
dc.rightsAcesso restrito
dc.sourceScopus
dc.subjectCapuchin monkey
dc.subjectCircadian timing system
dc.subjectMorphological analysis
dc.subjectSerotonergic afferent
dc.subjectanimal cell
dc.subjectanimal tissue
dc.subjectcircadian rhythm
dc.subjectcomparative study
dc.subjectcontrolled study
dc.subjectcytoarchitecture
dc.subjectmale
dc.subjectmarmoset
dc.subjectmonkey
dc.subjectnerve ending
dc.subjectnonhuman
dc.subjectpriority journal
dc.subjectrat
dc.subjectrodent
dc.subjectsensory nerve
dc.subjectserotoninergic nerve cell
dc.subjectserotoninergic system
dc.subjectspecies difference
dc.subjectsuprachiasmatic nucleus
dc.subjectAfferent Pathways
dc.subjectAnimals
dc.subjectCebus
dc.subjectHumans
dc.subjectImage Processing, Computer-Assisted
dc.subjectMale
dc.subjectRats
dc.subjectRats, Inbred LEC
dc.subjectRats, Wistar
dc.subjectSerotonin
dc.subjectSpecies Specificity
dc.subjectSuprachiasmatic Nucleus
dc.subjectAnimalia
dc.subjectCallithrix jacchus
dc.subjectCebus apella
dc.subjectMammalia
dc.subjectmarmosets
dc.subjectPrimates
dc.subjectRattus
dc.subjectRattus norvegicus
dc.subjectRodentia
dc.titleA comparative study of cytoarchitecture and serotonergic afferents in the suprachiasmatic nucleus of primates (Cebus apella and Callithrix jacchus) and rats (Wistar and Long Evans strains)
dc.typeArtigo


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