Transmission analysis of candidate genes for nonsyndromic oral clefts in Brazilian parent-child triads with recurrence

dc.contributorUniversidade Estadual Paulista (Unesp)
dc.contributorUniversidade de São Paulo (USP)
dc.contributorUniversity of Pittsburgh
dc.date.accessioned2014-05-27T11:21:58Z
dc.date.accessioned2022-10-05T18:03:02Z
dc.date.available2014-05-27T11:21:58Z
dc.date.available2022-10-05T18:03:02Z
dc.date.created2014-05-27T11:21:58Z
dc.date.issued2006-09-20
dc.identifierGenetics and Molecular Biology, v. 29, n. 3, p. 439-442, 2006.
dc.identifier1415-4757
dc.identifier1678-4685
dc.identifierhttp://hdl.handle.net/11449/69093
dc.identifier10.1590/S1415-47572006000300005
dc.identifierS1415-47572006000300005
dc.identifierWOS:000240328500005
dc.identifier2-s2.0-33748650083
dc.identifier2-s2.0-33748650083.pdf
dc.identifier0000-0002-9256-7623
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/3918584
dc.description.abstractCleft lip and/or palate (CL/P) is a major congenital defect with complex etiology, including multiple genetic and environmental factors. Approximately two thirds of the cases are not accompanied by other anomalies and are called nonsyndromic (NS). In the present study, we performed transmission distortion analysis of the MSX1-CA, TGFB3-CA and MTHFR-C677T polymorphisms in 60 parent-child triads, in which the NS-CL/ P affected child had at least one affected parent. No association with genes MSX1 or TGFB3 was found, but the results were suggestive of an association of the MTHFR-C677T polymorphism with NS-CL/P. © 2006 Sociedade Brasileira de Genética.
dc.languageeng
dc.relationGenetics and Molecular Biology
dc.relation1.493
dc.relation0,638
dc.rightsAcesso aberto
dc.sourceScopus
dc.subjectCleft lip
dc.subjectCleft palate
dc.subjectOral clefts
dc.subject5,10 methylenetetrahydrofolate reductase (FADH2)
dc.subjectDNA
dc.subjecttranscription factor MSX1
dc.subjecttransforming growth factor beta3
dc.subjectadult
dc.subjectallele
dc.subjectchild
dc.subjectcleft lip
dc.subjectcleft palate
dc.subjectDNA determination
dc.subjectfamily assessment
dc.subjectfemale
dc.subjectgene frequency
dc.subjectgene linkage disequilibrium
dc.subjectgene mapping
dc.subjectgenetic association
dc.subjectgenetic polymorphism
dc.subjectgenetic risk
dc.subjectgenotype
dc.subjectheredity
dc.subjecthuman
dc.subjectmajor clinical study
dc.subjectmale
dc.subjectpathophysiology
dc.subjectrisk assessment
dc.subjectsex difference
dc.titleTransmission analysis of candidate genes for nonsyndromic oral clefts in Brazilian parent-child triads with recurrence
dc.typeArtigo


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