Ethylcelullose microspheres containing sodium diclofenac: Development and characterization

dc.contributorUNIVALI
dc.contributorUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2014-05-27T11:21:54Z
dc.date.accessioned2022-10-05T18:02:09Z
dc.date.available2014-05-27T11:21:54Z
dc.date.available2022-10-05T18:02:09Z
dc.date.created2014-05-27T11:21:54Z
dc.date.issued2006-07-01
dc.identifierActa Farmaceutica Bonaerense, v. 25, n. 3, p. 401-404, 2006.
dc.identifier0326-2383
dc.identifierhttp://hdl.handle.net/11449/68975
dc.identifier2-s2.0-33845466134
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/3918475
dc.description.abstractThe objective of the present study was the development and characterization of ethylcellulose microspheres containing diclofenac and the determination of the in vitro drug release profile. Microspheres were prepared by emulsification/solvent evaporation method using ethyl acetate as solvent for the polymer and water as non solvent. The microspheres were characterized by morphologic and granulometric analyses. The amount of encapsulated drug as well as its release profile in vitro were also determined. The product obtained was microparticles with smooth surface and narrow size distribution, about 50% of the particles being smaller than 5 μm. The methodology used allowed drug encapsulation with a good yield and the system provided a controlled release of diclofenac.
dc.languageeng
dc.relationActa Farmaceutica Bonaerense
dc.relation0.401
dc.relation0,152
dc.rightsAcesso aberto
dc.sourceScopus
dc.subjectDiclofenac
dc.subjectEthylcellulose
dc.subjectMicroencapsulation
dc.subjectdiclofenac
dc.subjectethyl cellulose
dc.subjectmicrosphere
dc.subjectdrug delivery system
dc.subjectdrug release
dc.subjectemulsion
dc.subjectin vitro study
dc.subjectmethodology
dc.subjectmicroencapsulation
dc.subjectmorphology
dc.titleEthylcelullose microspheres containing sodium diclofenac: Development and characterization
dc.typeArtigo


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