Artigo
Estudo multicêntrico Brasileiro - Adesivo contraceptivo transdérmico semanal: Preferência e satisfação das usuárias
Fecha
2006-04-01Registro en:
Revista Brasileira de Medicina, v. 63, n. 4, p. 144-151, 2006.
0034-7264
2-s2.0-33744912791
9476843874583499
Autor
Universidade de São Paulo (USP)
Universidade Federal do Paraná (UFPR)
Faculdade de Ciências Médicas de Sorocaba
Gênesis Centro de Assistência e Reprodução Humana
Universidade Estadual Paulista (Unesp)
Universidade Federal de Goiás (UFG)
Universidade Federal de São Paulo (UNIFESP)
Universidade Federal do Rio Grande do Sul (UFRGS)
Hospital Maternidade Leonor Mendes de Barros (Casa Maternal)
Universidade Federal de Minas Gerais (UFMG)
Resumen
Background: To assess satisfaction with the weekly transdermal contraceptive patch, compared to the previous contraceptive method. Adhesion, cycle control, safety and efficacy were secondary outcomes. Methods: A multicenter, open label, descriptive study. Subjects received the weekly transdermal contraceptive patch for 6 cycles. At the baseline and after the 1 st, 3 rd and 6 th cycles, satisfaction with the method was assessed. The contraceptive efficacy was assessed by the Pearl Index and by life table analysis. Results: An ITT analysis was performed with 494 subjects. At the endpoint, 95.3% of women were satisfied with the patch compared to the previous method; 59.5%, 58.0% and 63.2% of women reported improvement in the physical and emotional well-being, and pre-menstrual symptoms, respectively. Pre-menstrual symptoms frequency decreased from 85.0% (CI 95%: 80.8-87.4%) to 55.0% (CI 95%: 49.9-66.0%). There was a significant increase in hemoglobin levels, and also a significant decrease in total serum cholesterol and tryglicerides.. There were no significant adverse events. The adjusted Pearl Index was 1.1 pregnancies per 100 women-years. Conclusions: The weekly contraceptive transdermal patch is a safe and effective method, and there was a high rate of satisfaction with its use among brazilian women. The patch was associated to a good cycle control, with easiness of use, improvement in the physical and emotional well-being and improvement in the premenstrual symptoms and lipid profile. © Copyright Moreira Jr. Editora. Todos os direitos reservados.